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@inproceedings{563687,
author = {Jansová, Eva and Krontorád, Petr and Svoboda, Zbyněk and Koutná, Irena and Pavlík, Tomáš and Kozubek, Michal and Jarošová, Marie and Žaloudík, Jan and Kozubek, Stanislav},
address = {Brno},
booktitle = {Biophysics of the Genome},
edition = {First Edition 2004},
keywords = {microarrays},
language = {eng},
location = {Brno},
isbn = {80-210-3560-9},
pages = {29-37},
publisher = {Masaryk University},
title = {Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches.},
year = {2004}
}
TY - JOUR
ID - 563687
AU - Jansová, Eva - Krontorád, Petr - Svoboda, Zbyněk - Koutná, Irena - Pavlík, Tomáš - Kozubek, Michal - Jarošová, Marie - Žaloudík, Jan - Kozubek, Stanislav
PY - 2004
TI - Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches.
PB - Masaryk University
CY - Brno
SN - 8021035609
KW - microarrays
N2 - We have compared colorectal carcinoma tissues with parallel samples of epithelial tissue and identified, by means of Human 1.7K cDNA microarrays, a set of genes with significantly altered expression in 12 patients. We used a combination of several approaches of microarray data analysis to be sure that the results were reliable. Although we have found differences between the results obtained by various image analysis software packages and using different statistical tools, we have identified the group of 22 genes with significantly altered expression in colorectal carcinoma tissue as compared with epithelial tissue using all evaluation approaches. Hierarchical clustering showed the possibility of dividing the patients into two groups according to the presence of metastases in regional lymph nodes. We have proposed 6 genes as potential markers for the detection of the presence of regional metastases in patients. We suppose that the proposed advance in the analysis of microarray data could lead to easier, quicker and more effective diagnostics of various diseases dependent on changes in the expression profile.
ER -
JANSOVÁ, Eva, Petr KRONTORÁD, Zbyněk SVOBODA, Irena KOUTNÁ, Tomáš PAVLÍK, Michal KOZUBEK, Marie JAROŠOVÁ, Jan ŽALOUDÍK a Stanislav KOZUBEK. Gene expression in colorectal carcinoma determined by cDNA microarrays using a combination of several evaluation approaches. In \textit{Biophysics of the Genome}. First Edition 2004. Brno: Masaryk University, 2004, s.~29-37. ISBN~80-210-3560-9.
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