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@proceedings{564259,
author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Šimurdová, Milena and Šimurda, Jiří},
booktitle = {Proceeding of Workshop in Cardiovascular Physiology: Signal transduction in Cardio-Vascular System},
keywords = {ionic currents; rate dependence; action potential; rat},
language = {eng},
title = {Membrane currents underlying rate-dependent changes of action potential in rat ventricular myocytes},
year = {2004}
}
TY - CONF
ID - 564259
AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Šimurdová, Milena - Šimurda, Jiří
PY - 2004
TI - Membrane currents underlying rate-dependent changes of action potential in rat ventricular myocytes
KW - ionic currents
KW - rate dependence
KW - action potential
KW - rat
N2 - The rate-dependent modulation of action potential (AP) playes an important role in the regulation of the excitation-contraction coupling and in the protective antiarrhythmic mechanisms in cardiac cells. We can conclude that the main determinants of rate-dependent variations of AP duration in rat ventricular myocytes are the calcium current ICa and the transient outward current Ito. Under our experimental conditions, participation of other current components was negligible.
ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Membrane currents underlying rate-dependent changes of action potential in rat ventricular myocytes. In \textit{Proceeding of Workshop in Cardiovascular Physiology: Signal transduction in Cardio-Vascular System}. 2004.
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