Další formáty:
BibTeX
LaTeX
RIS
@inproceedings{564351,
author = {Harničarová, Andrea and Bártová, Eva and Kozubek, Stanislav},
address = {Brno},
booktitle = {Biophysics of the Genome},
edition = {First Edition 2004},
keywords = {cytometry},
language = {eng},
location = {Brno},
isbn = {80-210-3560-9},
pages = {24-27},
publisher = {Masaryk University},
title = {Different nuclear localization of aberrant and normal chromosome 8 homologues in intact or NaBt differentiated HT-29 cells},
year = {2004}
}
TY - JOUR
ID - 564351
AU - Harničarová, Andrea - Bártová, Eva - Kozubek, Stanislav
PY - 2004
TI - Different nuclear localization of aberrant and normal chromosome 8 homologues in intact or NaBt differentiated HT-29 cells
PB - Masaryk University
CY - Brno
SN - 8021035609
KW - cytometry
N2 - An accumulation of numerous chromosomal structural aberrations is a typical feature of the human colon adenocarcinoma cell line HT-29. In these cells the chromosome 8 territories were visualized using fluorescence in situ hybridisation (FISH), which enabled to distinguish the aberrant chromosome 8 homologue from the normal one. Analyses of nuclear parameters revealed differences in radial positioning between chromosome homologues analysed. In comparison with an normal chromosome 8, the aberrant chromosome 8 territory was positioned closer to the nuclear periphery. Under standard conditions HT-29 cells displayed relatively undifferentiated phenotype but incubation of these cells in the presence of sodium butyrate (5mM) induced biochemical and morphological changes that are typical of well-differentiated phenotype of enterocytes. 2D analysis of the distances between centre of nucleus-to-centre of chromosome 8 territory revealed that sodium butyrate did not affect nuclear arrangem.
ER -
HARNIČAROVÁ, Andrea, Eva BÁRTOVÁ a Stanislav KOZUBEK. Different nuclear localization of aberrant and normal chromosome 8 homologues in intact or NaBt differentiated HT-29 cells. In \textit{Biophysics of the Genome}. First Edition 2004. Brno: Masaryk University, 2004, s.~24-27. ISBN~80-210-3560-9.
|
