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@proceedings{565138,
author = {Christé, Georges and Pásek, Michal and Šimurda, Jiří and Orchard, Clive},
booktitle = {Meeting of The Physiological Society (Oxford)},
keywords = {cardiac cell; tubular system; quantitative modelling},
language = {eng},
title = {Concentration changes in Ca2+ and K+ in the t-tubules of rat and guinea pig as estimated in two models of ventricular myocytes},
url = {http://www.physoc.org/custom/publications/proceedings/archive/article.asp?ID=J%20Physiol%20561PPC6},
year = {2004}
}
TY - CONF
ID - 565138
AU - Christé, Georges - Pásek, Michal - Šimurda, Jiří - Orchard, Clive
PY - 2004
TI - Concentration changes in Ca2+ and K+ in the t-tubules of rat and guinea pig as estimated in two models of ventricular myocytes
KW - cardiac cell
KW - tubular system
KW - quantitative modelling
UR - http://www.physoc.org/custom/publications/proceedings/archive/article.asp?ID=J%20Physiol%20561PPC6
N2 - To explore the possible role of t-tubular system in the physiological modulation of cardiac electrical and contractile activity, we designed mathematical models of guinea pig and rat ventricular cardiomyocytes in which the t-tubules were described as a single compartment. In both models, action potential responses to brief stimulations in current clamp are accompanied by transient K+ accumulation and transient Ca2+ depletion in the t-tubule lumen. The amplitude of these changes, relative to external ion concentrations, was studied at steady state at frequencies of 1 to 5 Hz. In the rat model, Ca2+ depletion increased from 11.8 % to 20.8 % with stimulation frequency. Meanwhile, K+ accumulation decreased from 4.3 % to 3 %. On the contrary, the guinea pig model exhibited decrease of tubular Ca2+ depletion from 15.6 % to 7.1 % and increase of tubular K+ accumulation from 2.5 % to 3.4 % in the same frequency range.
ER -
CHRISTÉ, Georges, Michal PÁSEK, Jiří ŠIMURDA a Clive ORCHARD. Concentration changes in Ca2+ and K+ in the t-tubules of rat and guinea pig as estimated in two models of ventricular myocytes. In \textit{Meeting of The Physiological Society (Oxford)}. 2004.
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