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@article{573874,
author = {Benes, Petr and Vashishta, Aruna and SaraswatandOhri, Sujata and Fusek, Martin and Pospisilova, Sarka and Tichy, Boris and Vetvicka, Vaclav},
article_location = {OXFORD},
article_number = {1},
keywords = {Breast cancer; Gene expression; Microarray analysis; Procathepsin D},
language = {eng},
issn = {0304-3835},
journal = {Cancer Letters},
title = {Effect of procathepsin D activation peptide on gene expression of breast cancer cells},
volume = {239},
year = {2006}
}
TY - JOUR
ID - 573874
AU - Benes, Petr - Vashishta, Aruna - Saraswat-Ohri, Sujata - Fusek, Martin - Pospisilova, Sarka - Tichy, Boris - Vetvicka, Vaclav
PY - 2006
TI - Effect of procathepsin D activation peptide on gene expression of breast cancer cells
JF - Cancer Letters
VL - 239
IS - 1
SP - 46-54
EP - 46-54
PB - ELSEVIER
SN - 03043835
KW - Breast cancer
KW - Gene expression
KW - Microarray analysis
KW - Procathepsin D
N2 - Overexpression of procathepsin D (pCD) is reported to occur in numerous types of cancer and is associated with increased growth and metastasis. It has been established that pCD affects multiple stages of tumor progression including proliferation, angiogenesis and metastasis. Previously, we showed that the mitogenic effect of pCD on cancer cells is mediated by interaction of its activation peptide (AP) with yet unidentified cell surface receptor. In this investigation, gene expression profiles were compared between AP-treated and control human breast cancer ZR-75-1 cells to elucidate the mechanism of AP mitogenicity. Several differentially expressed genes involved in signal transduction, regulation of cell cycle, apoptosis, tumor invasion and metastasis were identified using microarray technology. These findings, including overexpression of NFkappaB2, were confirmed in breast cancer cell lines by reverse-transcriptase PCR (RT-PCR). Understanding the mechanism of pCDs effect on breast cancer cells could extend possibilities of breast cancer treatment in the future.
ER -
BENES, Petr, Aruna VASHISHTA, Sujata SARASWAT-OHRI, Martin FUSEK, Sarka POSPISILOVA, Boris TICHY and Vaclav VETVICKA. Effect of procathepsin D activation peptide on gene expression of breast cancer cells. \textit{Cancer Letters}. OXFORD: ELSEVIER, 2006, vol.~239, No~1, p.~46-54. ISSN~0304-3835.
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