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@inproceedings{578801,
author = {Minaříková, Veronika and Hadašová, Eva and Siegmund, Werner and Moritz, KlausandUwe and Scheuch, Eberhard},
address = {Hradec Králové},
booktitle = {Sborník abstrakt. 55. česko-slovenských farmakologických dnů, 31.8.-2.9. 2005, Hradec Králové},
edition = {první},
keywords = {methamphetamine; metabolic enzymes; microsomes; rat},
language = {eng},
location = {Hradec Králové},
isbn = {80-86703-09-6},
pages = {30-30},
publisher = {Grafické studio, Olga Čermáková},
title = {Comparative study on the influence of methamphetamine and enzyme inducers on the activity of drug-metabolizing enzymes in the rat liver microsomes},
year = {2005}
}
TY - JOUR
ID - 578801
AU - Minaříková, Veronika - Hadašová, Eva - Siegmund, Werner - Moritz, Klaus-Uwe - Scheuch, Eberhard
PY - 2005
TI - Comparative study on the influence of methamphetamine and enzyme inducers on the activity of drug-metabolizing enzymes in the rat liver microsomes
PB - Grafické studio, Olga Čermáková
CY - Hradec Králové
SN - 8086703096
KW - methamphetamine
KW - metabolic enzymes
KW - microsomes
KW - rat
N2 - In the present study there was studied the influence of methamphetamine on the activity of cytochromes P450 and N-acetyltransferase (NAT)in the rat liver microsomes in comparison with the effect of known enzyme inducers: phenobarbital, beta-naphtoflavone and dexamethazone. Methamphetamine significantly inhibited CYP2E1, but, on the other hand, it stimulated NAT. Other investigated enzymes were not significantly influenced.
ER -
MINAŘÍKOVÁ, Veronika, Eva HADAŠOVÁ, Werner SIEGMUND, Klaus-Uwe MORITZ a Eberhard SCHEUCH. Comparative study on the influence of methamphetamine and enzyme inducers on the activity of drug-metabolizing enzymes in the rat liver microsomes. In \textit{Sborník abstrakt. 55. česko-slovenských farmakologických dnů, 31.8.-2.9. 2005, Hradec Králové}. první. Hradec Králové: Grafické studio, Olga Čermáková, 2005, s.~30-30. ISBN~80-86703-09-6.
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