ZAHRADNÍČKOVÁ, Eva, Karel SOUČEK, Viktor HORVÁTH a Jan ŠMARDA. Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts. In 13th Euroconference on Apoptosis. Budapest, Hungary: European Cell Death Organization, 2005, s. P-251, 1 s. ISBN 9632192737. |
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@inproceedings{580341, author = {Zahradníčková, Eva and Souček, Karel and Horváth, Viktor and Šmarda, Jan}, address = {Budapest, Hungary}, booktitle = {13th Euroconference on Apoptosis}, keywords = {v-Myb; apoptosis; autophagy; camptohecin}, language = {eng}, location = {Budapest, Hungary}, isbn = {9632192737}, pages = {P-251}, publisher = {European Cell Death Organization}, title = {Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts}, year = {2005} }
TY - JOUR ID - 580341 AU - Zahradníčková, Eva - Souček, Karel - Horváth, Viktor - Šmarda, Jan PY - 2005 TI - Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts PB - European Cell Death Organization CY - Budapest, Hungary SN - 9632192737 KW - v-Myb KW - apoptosis KW - autophagy KW - camptohecin N2 - A damage of programmed cell death pathways is a frequent event during malignant transformation. In this study, we analyzed programmed cell daeth (PCD) in v-myb-transformed BM2 and human U937 promonocytes induced by arsenic trioxide,cycloheximide and camtothecin. The presence of functional v-Myb protein pre-determined the BM2 cells to autophagic pathway of PCD in response to the DNA-damaging agents. The absence of transactivating v-Myb protein allowed activation of PCD pathway marked by mitochondrial membrane depolarization and resulting in necrosis. the fact that the antiapoptotic function of the Myb protein can be overcome by alternative PCD pathway suggests that understanding of molecular mechanisms of autophagy could improve therapy of cancer cells suffering from defective apoptosis. ER -
ZAHRADNÍČKOVÁ, Eva, Karel SOUČEK, Viktor HORVÁTH a Jan ŠMARDA. Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts. In \textit{13th Euroconference on Apoptosis}. Budapest, Hungary: European Cell Death Organization, 2005, s.~P-251, 1 s. ISBN~9632192737.
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