| ŠERÝ, Omar, Vladimír MIKEŠ, Renáta PITELOVÁ, Vladimír ZNOJIL a Petr ZVOLSKÝ. The association between high-activity COMT allele and alcoholism. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, roč. 27, č. 1, s. 231-235. ISSN 0172-780X. 2006. |
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@article{599986,
author = {Šerý, Omar and Mikeš, Vladimír and Pitelová, Renáta and Znojil, Vladimír and Zvolský, Petr},
article_location = {Sweden, Stockholm},
article_number = {1},
keywords = {alcohol dependence; association; COMT; Val158Met polymorphism; gene},
language = {eng},
issn = {0172-780X},
journal = {Neuroendocrinology Letters},
title = {The association between high-activity COMT allele and alcoholism},
volume = {27},
year = {2006}
}
TY - JOUR
ID - 599986
AU - Šerý, Omar - Mikeš, Vladimír - Pitelová, Renáta - Znojil, Vladimír - Zvolský, Petr
PY - 2006
TI - The association between high-activity COMT allele and alcoholism
JF - Neuroendocrinology Letters
VL - 27
IS - 1
SP - 231-235
EP - 231-235
PB - Maghira and Maas Publications
SN - 0172780X
KW - alcohol dependence
KW - association
KW - COMT
KW - Val158Met polymorphism
KW - gene
N2 - Objectives: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. The Val158Met polymorphism of the COMT gene has been previously associated with a variability of the COMT activity, and alcoholism. The aim of the present association study was to examine the relationship between the Val158Met polymorphism of the COMT gene and dispositions to alcoholism. Methods: In our case control study we analyzed DNA samples from 799 subjects in total (279 male alcoholics and 120 female alcoholics, 151 male controls and 249 female controls). The restriction analysis for the detection of the Val158Met polymorphism was used. Results: We found a relationship between the Val158Met polymorphism of the COMT gene and alcoholism in male subjects. We found the significant difference between male alcoholics and male controls in allele and genotype frequencies (p<0,007; and p<0,04 respectively). Conclusions: Our study confirmed the relationship between the COMT polymorphism and alcoholism in the Czech male population.
ER -
ŠERÝ, Omar, Vladimír MIKEŠ, Renáta PITELOVÁ, Vladimír ZNOJIL a Petr ZVOLSKÝ. The association between high-activity COMT allele and alcoholism. \textit{Neuroendocrinology Letters}. Sweden, Stockholm: Maghira and Maas Publications, roč.~27, č.~1, s.~231-235. ISSN~0172-780X. 2006.
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