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@inproceedings{602084,
author = {Dubový, Petr and Jančálek, Radim and Klusáková, Ilona and Svíženská, Ivana and Pejchalová, Kateřina},
address = {Košice},
booktitle = {Folia Medica Cassoviensia},
keywords = {dorsal root ganglia; TNF-alpha; TNFR1},
language = {eng},
location = {Košice},
isbn = {80-7097-607-1},
pages = {22-22},
publisher = {Institute of Neurobiology, Slovak Academy of Science},
title = {Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain},
year = {2005}
}
TY - JOUR
ID - 602084
AU - Dubový, Petr - Jančálek, Radim - Klusáková, Ilona - Svíženská, Ivana - Pejchalová, Kateřina
PY - 2005
TI - Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain
PB - Institute of Neurobiology, Slovak Academy of Science
CY - Košice
SN - 8070976071
KW - dorsal root ganglia
KW - TNF-alpha
KW - TNFR1
N2 - Peripheral neuropathic pain has been investigated using rat peripheral nerve injury models including unilateral sciatic nerve transection or ligation, spinal nerve ligation or ventral root transection. The experimental models were utilized for the study of immunofluorescence (IF) staining for IL-1b, IL-6, TNFa and TNFaR1 in the rat DRG. Quantitative and qualitative IF changes in the DRG affected by unilateral nerve injury were compared with the contralateral ones removed from operated animals as well as naive rats. Ipsi- and contralateral DRG displayed increased IF for TNFa and TNFaR1 when compared with DRG of naive rats. The TNFa IF was increased in both DRG neurons and their satellite glial cells, while enhanced IF for TNFaR1 was observed only at the surface of satellite glial cells after various types of nerve injury. In addition, ipsilateral DRG exhibited an elevation of TNFa immunoreactivity by invaded ED-1+ macrophages. The IL-1b IF was increased in the DRG neurons following sciatic nerve constriction, but not after the nerve trasection. A higher level of IF for IL-6 was observed in the DRG neurons and their satellite glial cells following sciatic nerve ligature as well as ventral root transection.
ER -
DUBOVÝ, Petr, Radim JANČÁLEK, Ilona KLUSÁKOVÁ, Ivana SVÍŽENSKÁ a Kateřina PEJCHALOVÁ. Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain. In \textit{Folia Medica Cassoviensia}. Košice: Institute of Neurobiology, Slovak Academy of Science, 2005. s.~22-22. ISBN~80-7097-607-1.
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