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@proceedings{622084,
author = {Šmajs, David and Matějková, Petra and Strouhal, Michal and Norris, S.J. and Weinstock, G.M.},
booktitle = {Abstract Book of NATO Advanced Research Workshop on Molecular Biology of Spirochetes},
keywords = {Treponema pallidum ssp. pallidum; Treponema pallidum ssp. pertenue; Treponema paraluiscuniculi},
language = {eng},
title = {Comparing genomes of pathogenic and non-pathogenic spirochetes: DNA-microarray hybridizations, whole genome fingerprinting and DNA sequencing.},
year = {2005}
}
TY - CONF
ID - 622084
AU - Šmajs, David - Matějková, Petra - Strouhal, Michal - Norris, S.J. - Weinstock, G.M.
PY - 2005
TI - Comparing genomes of pathogenic and non-pathogenic spirochetes: DNA-microarray hybridizations, whole genome fingerprinting and DNA sequencing.
KW - Treponema pallidum ssp. pallidum
KW - Treponema pallidum ssp. pertenue
KW - Treponema paraluiscuniculi
N2 - Genomes of closely related treponemes, Treponema pallidum ssp. pallidum (strains Nichols and SS14) and Treponema pallidum ssp. pertenue (Samoan D) were compared with the genome of Treponema paraluiscuniculi (strain Cuniculi A) using comparative genomic techniques. T. pallidum ssp. pallidum is the causative agent of highly invasive human disease syphilis, T. pallidum ssp. pertenue is the causative agent of yaws and T. paraluiscuniculi is not pathogenic to humans. When compared to Nichols genome, 1, 8 and 34 differences in the BamH I target restriction sites and 3, 7 and 20 indels were found in the genome of SS14, Samoan D and T. paraluiscuniculi, respectively.
ER -
ŠMAJS, David, Petra MATĚJKOVÁ, Michal STROUHAL, S.J. NORRIS a G.M. WEINSTOCK. Comparing genomes of pathogenic and non-pathogenic spirochetes: DNA-microarray hybridizations, whole genome fingerprinting and DNA sequencing. In \textit{Abstract Book of NATO Advanced Research Workshop on Molecular Biology of Spirochetes}. 2005.
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