| SABIN, Charles, Edward P. MITCHELL, Martina POKORNÁ, Catherine GAUTIER, J. UTILE, Michaela WIMMEROVÁ a Anne IMBERTY. Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: Thermodynamics data correlated with X-ray structures. FEBS Letters. Amsterdam: Elsevier Science B.V., 2006, roč. 580, č. 2, s. 982-987. ISSN 0014-5793. |
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@article{633505,
author = {Sabin, Charles and Mitchell, Edward P. and Pokorná, Martina and Gautier, Catherine and Utile, J. and Wimmerová, Michaela and Imberty, Anne},
article_location = {Amsterdam},
article_number = {2},
keywords = {Pseudomonas aeruginosa; lectin; cystic fibrosis},
language = {eng},
issn = {0014-5793},
journal = {FEBS Letters},
title = {Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: Thermodynamics data correlated with X-ray structures},
volume = {580},
year = {2006}
}
TY - JOUR
ID - 633505
AU - Sabin, Charles - Mitchell, Edward P. - Pokorná, Martina - Gautier, Catherine - Utile, J. - Wimmerová, Michaela - Imberty, Anne
PY - 2006
TI - Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: Thermodynamics data correlated with X-ray structures
JF - FEBS Letters
VL - 580
IS - 2
SP - 982-987
EP - 982-987
PB - Elsevier Science B.V.
SN - 00145793
KW - Pseudomonas aeruginosa
KW - lectin
KW - cystic fibrosis
N2 - The PA-IIL lectin from Pseudomonas aeruginosa is involved in host recognition and biofilm formation. The lectin displays an unusually high affinity for fucose but also binds to L-fucose, L-galactose and D-arabinose that differ only by the group at position 5 of the sugar ring. ITC experiments provided precise determination of affinity for the three methyl-glycosides and revealed a large enthalpy contribution. The crystal structures of the complexes of PA-IIL with L-galactose and Met-â-D-arabinoside have been determined and compared with the PA-IIL/fucose complex described previously. Combination of structures and thermodynamics provided clues for the role of the hydrophobic group in affinity.
ER -
SABIN, Charles, Edward P. MITCHELL, Martina POKORNÁ, Catherine GAUTIER, J. UTILE, Michaela WIMMEROVÁ a Anne IMBERTY. Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: Thermodynamics data correlated with X-ray structures. \textit{FEBS Letters}. Amsterdam: Elsevier Science B.V., 2006, roč.~580, č.~2, s.~982-987. ISSN~0014-5793.
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