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@proceedings{636311,
author = {Kaňková, Kateřina and Kalousová, Marta and Hertlová, Miluše and Krusová, Darja and Zima, Tomáš},
booktitle = {The Maillard Reaction in Food and Medicine},
keywords = {diabetic nephropathy; RAGE; polymorphism; sRAGE; renal failure},
language = {eng},
title = {Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy},
year = {2006}
}
TY - CONF
ID - 636311
AU - Kaňková, Kateřina - Kalousová, Marta - Hertlová, Miluše - Krusová, Darja - Zima, Tomáš
PY - 2006
TI - Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy
KW - diabetic nephropathy
KW - RAGE
KW - polymorphism
KW - sRAGE
KW - renal failure
N2 - RAGE2 haplotype was previously identified as a genetic risk factor for the development and early onset of diabetic nephropathy. Curent study showed that (i) sRAGE significantly differed among subjects bearing variable number of RAGE2 haplotype copies, (ii) was significantly higher in subjects with nephropathy than normoalbuminuric patients and (iii) positively correlated with severity of nephropathy, S-urea, S-creatinine and negatively with glomerular filtration rate (GFR). GFR seems to be principal determinant of the AGE and sRAGE levels.
ER -
KAŇKOVÁ, Kateřina, Marta KALOUSOVÁ, Miluše HERTLOVÁ, Darja KRUSOVÁ a Tomáš ZIMA. Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy. In \textit{The Maillard Reaction in Food and Medicine}. 2006.
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