Trapped water molecules are essential to structural dynamics and function of a ribozyme

RHODES, Maria, Kamila REBLOVA, Walter NILS and Jiri SPONER. Trapped water molecules are essential to structural dynamics and function of a ribozyme. The Proceedings of the National Academy of Sciences. USA: National Academy of Sciences of the USA, 2006, vol. 103, No 36, p. 13380-13385. ISSN 1091-6490.

Basic information

Original name

Trapped water molecules are essential to structural dynamics and function of a ribozyme

Name in Czech

Zachycené molekuly vod jsou esenciální pro strukturní dynamiku a funkci ribozymů

Authors

RHODES, Maria (840 United States of America), Kamila REBLOVA (203 Czech Republic), Walter NILS (840 United States of America) and Jiri SPONER (203 Czech Republic, guarantor)

Edition

The Proceedings of the National Academy of Sciences, USA, National Academy of Sciences of the USA, 2006, 1091-6490

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10610 Biophysics

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/06:00017097

Organization unit

Faculty of Science

UT WoS

000240512700024

Keywords in English

coupled molecular motions; hairpin ribozyme; molecular dynamics; proton wire

Tags

coupled molecular motions, hairpin ribozyme, molecular dynamics, proton wire

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Abstract

V originále

Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network.

In Czech

Kombináciou explicit-solvent molekulovej dynamiky a single-molecule fluorescenčnej spektroskopie, sme našli, že ribozyme zo subvirálneho rastinného patogénu vykazuje zpriahnutú sieť vodíkových vazieb ktoré prenášajú dynamické štrukturálne zmeny naprieč katalytickým centrom ako odozva miestne-riadenej chemickej modifikácie. Zachytené molekuly vody su rozhodujúce pre túto sieť.

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Links

MSM0021622413, plan (intention)

Name: Proteiny v metabolismu a při interakci organismů s prostředím Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment