RHODES, Maria, Kamila REBLOVA, Walter NILS and Jiri SPONER. Trapped water molecules are essential to structural dynamics and function of a ribozyme. The Proceedings of the National Academy of Sciences, USA: National Academy of Sciences of the USA, 2006, vol. 103, No 36, p. 13380-13385. ISSN 1091-6490.
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Basic information
Original name Trapped water molecules are essential to structural dynamics and function of a ribozyme
Name in Czech Zachycené molekuly vod jsou esenciální pro strukturní dynamiku a funkci ribozymů
Authors RHODES, Maria (840 United States of America), Kamila REBLOVA (203 Czech Republic), Walter NILS (840 United States of America) and Jiri SPONER (203 Czech Republic, guarantor).
Edition The Proceedings of the National Academy of Sciences, USA, National Academy of Sciences of the USA, 2006, 1091-6490.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10610 Biophysics
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/06:00017097
Organization unit Faculty of Science
UT WoS 000240512700024
Keywords in English coupled molecular motions; hairpin ribozyme; molecular dynamics; proton wire
Tags coupled molecular motions, hairpin ribozyme, molecular dynamics, proton wire
Changed by Changed by: Mgr. Kamila Réblová, Ph.D., učo 11846. Changed: 4/9/2006 08:27.
Abstract
Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network.
Abstract (in Czech)
Kombináciou explicit-solvent molekulovej dynamiky a single-molecule fluorescenčnej spektroskopie, sme našli, že ribozyme zo subvirálneho rastinného patogénu vykazuje zpriahnutú sieť vodíkových vazieb ktoré prenášajú dynamické štrukturálne zmeny naprieč katalytickým centrom ako odozva miestne-riadenej chemickej modifikácie. Zachytené molekuly vody su rozhodujúce pre túto sieť.
Links
MSM0021622413, plan (intention)Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Research Intents
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