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@inproceedings{699186,
author = {Navrátilová, Jarmila and Horváth, Viktor and Kozubík, Alois and Lojek, Antonín and Šmarda, Jan},
address = {Lausanne, Švýcarsko},
booktitle = {ISREC conference on cancer research},
keywords = {p53; v-Myb; differentiation; cell cycle; apoptosis},
language = {eng},
location = {Lausanne, Švýcarsko},
isbn = {nepřiděleno},
pages = {77-77},
publisher = {Swiss Institute for Experimental Cancer Research},
title = {p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts},
year = {2006}
}
TY - JOUR
ID - 699186
AU - Navrátilová, Jarmila - Horváth, Viktor - Kozubík, Alois - Lojek, Antonín - Šmarda, Jan
PY - 2006
TI - p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts
PB - Swiss Institute for Experimental Cancer Research
CY - Lausanne, Švýcarsko
SN - nepřiděleno
KW - p53
KW - v-Myb
KW - differentiation
KW - cell cycle
KW - apoptosis
N2 - v-Myb oncoprotein of AMV interferes with differentiation of myeloid cells. Differentiation of v-Myb-transformed monoblasts BM2 can be resumed by phorbol ester TPA or histone deacetylase inhibitor trichostatin A. The aim of this work was to explore the effects of the p53 tumor suppressor on proliferation, viability, cell cycle progression, apoptosis and differentiation of BM2 cells. We found that ectopic p53 expression completely suppresses proliferation of BM2 cells by imposing block in the G2 phase of the cell cycle. In addition, p53 induces differentiation of BM2 monoblasts to monocytes, as confirmed by up-regulation of production of reactive oxygen species, expression of CD11b, non-specific esterase and myeloperoxidase activities, and by changes of the intracellular pH. In contrast, frequency of apoptosis was not affected by overexpressed p53 in BM2 cells.
ER -
NAVRÁTILOVÁ, Jarmila, Viktor HORVÁTH, Alois KOZUBÍK, Antonín LOJEK and Jan ŠMARDA. p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts. In \textit{ISREC conference on cancer research}. Lausanne, Švýcarsko: Swiss Institute for Experimental Cancer Research, 2006, p.~77-77. ISBN~nepřiděleno.
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