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@article{699877,
author = {Bienertová Vašků, Julie and Vašků, Anna and Dostálová, Zuzana and Bienert, Petr},
article_number = {2},
keywords = {Gestational Diabetes Mellitus; Leptin; Polymorphism; Preeclampsia},
language = {eng},
issn = {1555-8932},
journal = {Genes and Nutrition},
title = {ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES},
url = {www.newcentruyhealthpublishers.com},
volume = {2/2006},
year = {2006}
}
TY - JOUR
ID - 699877
AU - Bienertová Vašků, Julie - Vašků, Anna - Dostálová, Zuzana - Bienert, Petr
PY - 2006
TI - ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES
JF - Genes and Nutrition
VL - 2/2006
IS - 2
SP - 117-124
EP - 117-124
PB - New Century Health Publishers
SN - 15558932
KW - Gestational Diabetes Mellitus
KW - Leptin
KW - Polymorphism
KW - Preeclampsia
UR - www.newcentruyhealthpublishers.com
N2 - The aim of this study was to investigate possible associations of -2548 G/A polymorphism in leptin gene promoter and pregnancy-associated diseases with abnormal fetal growth such as preeclampsia and gestational diabetes. The study was also focused on whether it is rather maternal or fetal variants that determines the pathological growth status. Peripheral or cord blood samples obtained from 49 preeclamptic women and their 39 newborns, 53 healthy controls and their 53 healthy newborns and 48 patients with gestational diabetes mellitus were evaluated for leptin gene (LEP) locus -2548 genotypes. The significantly higher risk for gestational diabetes mellitus was observed in the presence of an allele (AA and AG genotypes) against carriers of GG genotype (OR=2.84, 95%CI 1.14-7.07, p=0.02). There is a significant risk of diabetes mellitus associated to A allele (OR=1.79, 95%CI 1.02-3.14, p=0.03). Furthermore, evaluations of preeclamptic patients data revealed a significant association of genotype distribution and delivery and spontaneous abortion rate, where the GG carriers performed the highest pregnancy rate while the AG carriers performed the lowest spontaneous abortion rate. Our results support the hypothesis for -2548 G/A leptin gene polymorphism involvement in ethiopathogenesis of pregnancy-associated diseases with abnormal fetal growth, especially gestational diabetes mellitus.
ER -
BIENERTOVÁ VAŠKŮ, Julie, Anna VAŠKŮ, Zuzana DOSTÁLOVÁ a Petr BIENERT. ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES. \textit{Genes and Nutrition}. New Century Health Publishers, 2006, roč.~2/2006, č.~2, s.~117-124, 5 s. ISSN~1555-8932.
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