ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH
GESTATIONAL DIABETES

J 2006

ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES

BIENERTOVÁ VAŠKŮ, Julie, Anna VAŠKŮ, Zuzana DOSTÁLOVÁ a Petr BIENERT

Základní údaje

Originální název

ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES

Název česky

Asociace genetického polymorfismu -2548 G/A v genu pro leptin s gestačním diabetem

Autoři

BIENERTOVÁ VAŠKŮ, Julie (203 Česká republika, garant), Anna VAŠKŮ (203 Česká republika), Zuzana DOSTÁLOVÁ (203 Česká republika) a Petr BIENERT (203 Česká republika)

Vydání

Genes and Nutrition, New Century Health Publishers, 2006, 1555-8932

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/06:00017421

Organizační jednotka

Lékařská fakulta

UT WoS

000258559500006

Klíčová slova anglicky

Gestational Diabetes Mellitus; Leptin; Polymorphism; Preeclampsia

Štítky

gestational diabetes mellitus, leptin, polymorphism, preeclampsia

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 6. 2009 08:15, prof. MUDr. Anna Vašků, CSc.

Anotace

ORIG CZ

V originále

The aim of this study was to investigate possible associations of -2548 G/A polymorphism in leptin gene promoter and pregnancy-associated diseases with abnormal fetal growth such as preeclampsia and gestational diabetes. The study was also focused on whether it is rather maternal or fetal variants that determines the pathological growth status. Peripheral or cord blood samples obtained from 49 preeclamptic women and their 39 newborns, 53 healthy controls and their 53 healthy newborns and 48 patients with gestational diabetes mellitus were evaluated for leptin gene (LEP) locus -2548 genotypes. The significantly higher risk for gestational diabetes mellitus was observed in the presence of an allele (AA and AG genotypes) against carriers of GG genotype (OR=2.84, 95%CI 1.14-7.07, p=0.02). There is a significant risk of diabetes mellitus associated to A allele (OR=1.79, 95%CI 1.02-3.14, p=0.03). Furthermore, evaluations of preeclamptic patients data revealed a significant association of genotype distribution and delivery and spontaneous abortion rate, where the GG carriers performed the highest pregnancy rate while the AG carriers performed the lowest spontaneous abortion rate. Our results support the hypothesis for -2548 G/A leptin gene polymorphism involvement in ethiopathogenesis of pregnancy-associated diseases with abnormal fetal growth, especially gestational diabetes mellitus.

Česky

Získaná data naznačují, ze variabilita v genu pro leptin, konkrétně definovaný polymorfismus -2548 G/A se může uplatnit jako etiopatogenetický faktor při vzniku gestačního diabetu nebo obecně při poruchách fetálního růstu.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Anna VAŠKŮ, Zuzana DOSTÁLOVÁ a Petr BIENERT. ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES. Genes and Nutrition. New Century Health Publishers, 2006, roč. 2/2006, č. 2, s. 117-124, 5 s. ISSN 1555-8932.

@article{699877,
   author = {Bienertová Vašků, Julie and Vašků, Anna and Dostálová, Zuzana and Bienert, Petr},
   article_number = {2},
   keywords = {Gestational Diabetes Mellitus; Leptin; Polymorphism; Preeclampsia},
   language = {eng},
   issn = {1555-8932},
   journal = {Genes and Nutrition},
   title = {ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES},
   url = {www.newcentruyhealthpublishers.com},
   volume = {2/2006},
   year = {2006}
}

TY  - JOUR
ID  - 699877
AU  - Bienertová Vašků, Julie - Vašků, Anna - Dostálová, Zuzana - Bienert, Petr
PY  - 2006
TI  - ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES
JF  - Genes and Nutrition
VL  - 2/2006
IS  - 2
SP  - 117-124
EP  - 117-124
PB  - New Century Health Publishers
SN  - 15558932
KW  - Gestational Diabetes Mellitus
KW  - Leptin
KW  - Polymorphism
KW  - Preeclampsia
UR  - www.newcentruyhealthpublishers.com
N2  - The aim of this study was to investigate possible associations of -2548 G/A polymorphism in leptin gene promoter and pregnancy-associated diseases with abnormal fetal growth such as preeclampsia and gestational diabetes. The study was also focused on whether it is rather maternal or fetal variants that determines the pathological growth status. Peripheral or cord blood samples obtained from 49 preeclamptic women and their 39 newborns, 53 healthy controls and their 53 healthy newborns and 48 patients with gestational diabetes mellitus were evaluated for leptin gene (LEP) locus -2548 genotypes. The significantly higher risk for gestational diabetes mellitus was observed in the presence of an allele (AA and AG genotypes) against carriers of GG genotype (OR=2.84, 95%CI 1.14-7.07, p=0.02). There is a significant risk of diabetes mellitus associated to A allele (OR=1.79, 95%CI 1.02-3.14, p=0.03). Furthermore, evaluations of preeclamptic patients data revealed a significant association of genotype distribution and delivery and spontaneous abortion rate, where the GG carriers performed the highest pregnancy rate while the AG carriers performed the lowest spontaneous abortion rate. Our results support the hypothesis for -2548 G/A leptin gene polymorphism involvement in ethiopathogenesis of pregnancy-associated diseases with abnormal fetal growth, especially gestational diabetes mellitus.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Anna VAŠKŮ, Zuzana DOSTÁLOVÁ a Petr BIENERT. ASSOCIATION OF LEPTIN GENETIC POLYMORPHISM -2548 G/A WITH GESTATIONAL DIABETES. \textit{Genes and Nutrition}. New Century Health Publishers, 2006, roč.~2/2006, č.~2, s.~117-124, 5 s. ISSN~1555-8932.

Podrobný výpis o publikaci