The gene for interleukin 6: the candidate gene for
neuropsychiatric illness?

J 2006

The gene for interleukin 6: the candidate gene for neuropsychiatric illness?

ŠERÝ, Omar; Radim ŠTAIF; Renáta PITELOVÁ; Jan LOCHMAN; Vladimír MIKEŠ et. al.

Základní údaje

Originální název

The gene for interleukin 6: the candidate gene for neuropsychiatric illness?

Název česky

Gen pro interleukin 6: kandidátní gen neuropsychiatrických chorob?

Autoři

ŠERÝ, Omar; Radim ŠTAIF; Renáta PITELOVÁ; Jan LOCHMAN; Vladimír MIKEŠ; Ivana DRTÍLKOVÁ a Petr ZVOLSKÝ

Vydání

American Journal of Medical Genetics, Hoboken, NJ, Wiley-Liss, Inc. 2006, 1552-4841

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.463

Kód RIV

RIV/00216224:14310/06:00017435

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000240877700194

Klíčová slova anglicky

IL-6; polymorphism; alcohol dependence; ADHD

Štítky

ADHD, alcohol dependence, IL-6, polymorphism

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 2. 2008 17:34, prof. RNDr. Omar Šerý, Ph.D.

Anotace

ORIG CZ

V originále

IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. Genetic variation (-174 G/C polymorphism) in the promoter region of the IL-6 gene influences the expression of IL-6. Our objective was to determine whether -174 G/C polymorphism of IL-6 is associated with alcoholism and ADHD. In our two independent association studies, we investigated the relationship between above mentioned polymorphism and alcoholism in 400 alcoholics and 400 controls, and in ADHD study in 49 hyperactive boys and 40 control boys. We found a statistically significant difference (p<0.03) in allelic frequencies between alcoholics and controls and statistically significant difference (p<0.001) between controls and ADHD subjects using Fisher exact test. The C allele was observed more frequently in alcoholics, as well as in ADHD group of boys in comparing with control subjects. Our association studies provided new data about the relationship between -174 G/C polymorphism of IL-6 gene and alcoholism/ADHD. These findings highlight the need for further investigations of the influence of cytokine genes on pathogenesis of variable psychiatric disorders. In according with recent in vitro experiments, we expect the finding of the relationship between studied IL-6 polymorphism and the embryonal development of specific human brain structures.

Česky

IL-6 je kandidátním genem neuropsychiatrických poruch. Nalezli jsme vztah polymorfizmu tohoto genu k ADHD i alkoholizmu. Další studium by mělo tento vztah vyvrátit nebo potvrdit.

Návaznosti

MSM0021622413, záměr

Název: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Proteiny v metabolismu a při interakci organismů s prostředím

NR8137, projekt VaV

Název: Molekulární příčiny dispozic ke vzniku alkoholizmu.

Investor: Ministerstvo zdravotnictví ČR, Molekulární příčiny dispozic ke vzniku alkoholizmu

Citovat

ŠERÝ, Omar; Radim ŠTAIF; Renáta PITELOVÁ; Jan LOCHMAN; Vladimír MIKEŠ; Ivana DRTÍLKOVÁ a Petr ZVOLSKÝ. The gene for interleukin 6: the candidate gene for neuropsychiatric illness? American Journal of Medical Genetics. Hoboken, NJ: Wiley-Liss, Inc., 2006, roč. 141B, č. 7, s. 728. ISSN 1552-4841.

@article{699929,
   author = {Šerý, Omar and Štaif, Radim and Pitelová, Renáta and Lochman, Jan and Mikeš, Vladimír and Drtílková, Ivana and Zvolský, Petr},
   article_location = {Hoboken, NJ},
   article_number = {7},
   keywords = {IL-6; polymorphism; alcohol dependence; ADHD},
   language = {eng},
   issn = {1552-4841},
   journal = {American Journal of Medical Genetics},
   title = {The gene for interleukin 6: the candidate gene for neuropsychiatric illness?},
   volume = {141B},
   year = {2006}
}

TY  - JOUR
ID  - 699929
AU  - Šerý, Omar - Štaif, Radim - Pitelová, Renáta - Lochman, Jan - Mikeš, Vladimír - Drtílková, Ivana - Zvolský, Petr
PY  - 2006
TI  - The gene for interleukin 6: the candidate gene for neuropsychiatric illness?
JF  - American Journal of Medical Genetics
VL  - 141B
IS  - 7
SP  - 728
EP  - 728
PB  - Wiley-Liss, Inc.
SN  - 15524841
KW  - IL-6
KW  - polymorphism
KW  - alcohol dependence
KW  - ADHD
N2  - IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. Genetic variation (-174 G/C polymorphism) in the promoter region of the IL-6 gene influences the expression of IL-6. Our objective was to determine whether -174 G/C polymorphism of IL-6 is associated with alcoholism and ADHD. In our two independent association studies, we investigated the relationship between above mentioned polymorphism and alcoholism in 400 alcoholics and 400 controls, and in ADHD study in 49 hyperactive boys and 40 control boys. We found a statistically significant difference (p<0.03) in allelic frequencies between alcoholics and controls and statistically significant difference (p<0.001) between controls and ADHD subjects using Fisher exact test. The C allele was observed more frequently in alcoholics, as well as in ADHD group of boys in comparing with control subjects. Our association studies provided new data about the relationship between -174 G/C polymorphism of IL-6 gene and alcoholism/ADHD. These findings highlight the need for further investigations of the influence of cytokine genes on pathogenesis of variable psychiatric disorders. In according with recent in vitro experiments, we expect the finding of the relationship between studied IL-6 polymorphism and the embryonal development of specific human brain structures.
ER  -

ŠERÝ, Omar; Radim ŠTAIF; Renáta PITELOVÁ; Jan LOCHMAN; Vladimír MIKEŠ; Ivana DRTÍLKOVÁ a Petr ZVOLSKÝ. The gene for interleukin 6: the candidate gene for neuropsychiatric illness? \textit{American Journal of Medical Genetics}. Hoboken, NJ: Wiley-Liss, Inc., 2006, roč.~141B, č.~7, s.~728. ISSN~1552-4841.

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