ŠTAIF, Radim, Omar ŠERÝ, Renáta PITELOVÁ, Jan LOCHMAN, Vladimír MIKEŠ, Ivana DRTÍLKOVÁ and Pavel THEINER. A case-control study of the relationship between 13 candidate genes and ADHD. American Journal of Medical Genetics. Hoboken, NJ: Wiley-Liss, Inc., 2006, 141B, No 7, p. 729-730. ISSN 1552-4841.
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Basic information
Original name A case-control study of the relationship between 13 candidate genes and ADHD
Name in Czech Asociační studie vztahu mezi 13 kandidátními geny a ADHD
Authors ŠTAIF, Radim (203 Czech Republic), Omar ŠERÝ (203 Czech Republic, guarantor), Renáta PITELOVÁ (203 Czech Republic), Jan LOCHMAN (203 Czech Republic), Vladimír MIKEŠ (203 Czech Republic), Ivana DRTÍLKOVÁ (203 Czech Republic) and Pavel THEINER (203 Czech Republic).
Edition American Journal of Medical Genetics, Hoboken, NJ, Wiley-Liss, Inc. 2006, 1552-4841.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.463
RIV identification code RIV/00216224:14310/06:00017436
Organization unit Faculty of Science
UT WoS 000240877700202
Keywords in English ADHD; polymorphism; DAT1; DRD2; COMT; MAOB; ACE; ANG; CCR5; BDNF; MU; IL-2; IL-6; TNF; M235T
Tags ACE, ADHD, ANG, BDNF, CCR5, COMT, DAT1, DRD2, IL-2, IL-6, M235T, MAOB, MU, polymorphism, TNF
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Omar Šerý, Ph.D., učo 18120. Changed: 13/2/2008 17:31.
Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. The other genes from neurotransmitter and immune system are in focus too. We have investigated whether there is an association between ADHD and polymorphisms of 13 candidate genes: DAT1, DRD2, COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha, and M235T. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined polymorphisms of the above mentioned genes compared to controls (153). No significant differences were found between groups of boys in allelic and genotype frequencies of COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha and M235T genes (p < 0.05). For DAT1, the statistical analysis using Fisher exact test did not confirme the association of the previously possitive investigated 10-repeat allele or 10/10 genotype of DAT1 gene (p = 0.531). For DRD2, ADHD probands were more likely than controls to have the A1 allele and genotype A1A1 (p = 0.0013). Our results showed that ADHD in Czech children population is associated with TaqI A polymorphism of DRD2 gene. The presence of DRD2 A1 allele increases the risk of ADHD.
Abstract (in Czech)
Při zkoumání vztahu mezi ADHD a 13-ti polymorfizmy kandidátních genů jsme objevili vztah mezi genem pro DAT1, DRD2 a ADHD.
MSM0021622413, plan (intention)Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment
NR8137, research and development projectName: Molekulární příčiny dispozic ke vzniku alkoholizmu.
Investor: Ministry of Health of the CR
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