Are leptin gene promoter polymorphisms associated with
restenosis after coronary stenting?

D 2006

Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting?

BIENERTOVÁ VAŠKŮ, Julie, Ota HLINOMAZ and Anna VAŠKŮ

Basic information

Original name

Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting?

Name in Czech

Variabilita v genu pro leptin u pacientů s restenózou po PCI

Authors

BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor), Ota HLINOMAZ (203 Czech Republic) and Anna VAŠKŮ (203 Czech Republic)

Edition

Hungary, New Frontiers in Basic Cardiovascular Research, p. 51-51, 1 pp. 2006

Publisher

INSERM, France

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

Genetics and molecular biology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/06:00017440

Organization unit

Faculty of Medicine

Keywords in English

Genes; restenosis; polymerase chain reaction; leptin; polymorphism

Abstract

ORIG CZ

V originále

Background: The hypertrophy of vascular smooth muscle cells as well as neointimal proliferation is critical in vascular remodelling associated with restenosis after PCI. Leptin has recently proved to play an important role in vascular remodelling. Objectives: In this study, we investigated possible associations of two leptin gene promoter polymorphisms and restenosis after PTCA. Methods: To study possible association of two promoter polymorphisms LEP -2548 G/A and LEP-188 A/C with neointimal proliferation in humans, 98 consecutive patients undergoing stenting into small coronary arteries (<3mm) were genotyped. Restenosis was identified by quantitative coronary angiography after 6 months. Results: The restenosis > 50% occurred in 33.3% patients carrying both A alleles, 33.3% carriers of A and C alleles and 31.4% carriers of two CC alleles of LEP -188 C/A polymorphism and in 25.0% patients with AA, 32.7% with AG and 30.4% with GG genotype of LEP -2548 G/A polymorphism. Interestingly, the heterozygote AG genotype of LEP -2548 polymorphism represented a highly statistically significant risk for multiple vessel disease when compared to both homozygote genotypes AA/GG (OR=4.038, 95% CI: 1.732-9.465, p=0.0009). Conclusions: Based on our results we hypothesize that AG genotype of LEP -2548 G/A polymorphism might be considered a genetic marker for multiple vessel disease. However, the role of leptin in pathogenesis of restenosis still remains to be elucidated.

In Czech

Leptin se zdá být možným modulátorem v rámci neointimální proliferace, na základě našich výsledků se heterozygotní genotyp AG polymorfismu LEP-2548 G/A jeví jako slibný genetický marker pro multiple vessel disease. Úloha tohoto polymorfismu v patogenezi restenózy po PCI vyžaduje další výzkum.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Ota HLINOMAZ and Anna VAŠKŮ. Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting? In New Frontiers in Basic Cardiovascular Research. Hungary: INSERM, France, 2006, p. 51-51.

@inproceedings{699943,
   author = {Bienertová Vašků, Julie and Hlinomaz, Ota and Vašků, Anna},
   address = {Hungary},
   booktitle = {New Frontiers in Basic Cardiovascular Research},
   keywords = {Genes; restenosis; polymerase chain reaction; leptin; polymorphism},
   language = {eng},
   location = {Hungary},
   pages = {51-51},
   publisher = {INSERM, France},
   title = {Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting?},
   year = {2006}
}

TY  - JOUR
ID  - 699943
AU  - Bienertová Vašků, Julie - Hlinomaz, Ota - Vašků, Anna
PY  - 2006
TI  - Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting?
PB  - INSERM, France
CY  - Hungary
KW  - Genes
KW  - restenosis
KW  - polymerase chain reaction
KW  - leptin
KW  - polymorphism
N2  - Background: The hypertrophy of vascular smooth muscle cells as well as neointimal proliferation is critical in vascular remodelling associated with restenosis after PCI. Leptin has recently proved to play an important role in vascular remodelling. Objectives: In this study, we investigated possible associations of two leptin gene promoter polymorphisms and restenosis after PTCA. Methods: To study possible association of two promoter polymorphisms LEP -2548 G/A and LEP-188 A/C with neointimal proliferation in humans, 98 consecutive patients undergoing stenting into small coronary arteries (<3mm) were genotyped. Restenosis was identified by quantitative coronary angiography after 6 months. Results: The restenosis > 50% occurred in 33.3% patients carrying both A alleles, 33.3% carriers of A and C alleles and 31.4% carriers of two CC alleles of LEP -188 C/A polymorphism and in 25.0% patients with AA, 32.7% with AG and 30.4% with GG genotype of LEP -2548 G/A polymorphism. Interestingly, the heterozygote AG genotype of LEP -2548 polymorphism represented a highly statistically significant risk for multiple vessel disease when compared to both homozygote genotypes AA/GG (OR=4.038, 95% CI: 1.732-9.465, p=0.0009). Conclusions: Based on our results we hypothesize that AG genotype of LEP -2548 G/A polymorphism might be considered a genetic marker for multiple vessel disease. However, the role of leptin in pathogenesis of restenosis still remains to be elucidated.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Ota HLINOMAZ and Anna VAŠKŮ. Are leptin gene promoter polymorphisms associated with restenosis after coronary stenting? In \textit{New Frontiers in Basic Cardiovascular Research}. Hungary: INSERM, France, 2006, p.~51-51.

Detailed Information on Publication Record