| BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK a Marie NOVÁKOVÁ. Effect of haloperidol on transient outward potassium current in rat ventricular myocytes. European Journal of Pharmacology. Amsterdam, The Netherlands: Elsevier Science B.V., 2006, roč. 550, 1-3, s. 15-23. ISSN 0014-2999. |
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@article{700534,
author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Nováková, Marie},
article_location = {Amsterdam, The Netherlands},
article_number = {1-3},
keywords = {haloperidol; transient outward current; sigma receptors; rat ventricular myocytes; whole-cell pach clamp; quantitative model},
language = {eng},
issn = {0014-2999},
journal = {European Journal of Pharmacology},
title = {Effect of haloperidol on transient outward potassium current in rat ventricular myocytes},
volume = {550},
year = {2006}
}
TY - JOUR
ID - 700534
AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Nováková, Marie
PY - 2006
TI - Effect of haloperidol on transient outward potassium current in rat ventricular myocytes
JF - European Journal of Pharmacology
VL - 550
IS - 1-3
SP - 15-23
EP - 15-23
PB - Elsevier Science B.V.
SN - 00142999
KW - haloperidol
KW - transient outward current
KW - sigma receptors
KW - rat ventricular myocytes
KW - whole-cell pach clamp
KW - quantitative model
N2 - Haloperidol induced a decrease of amplitude and an acceleration of apparent inactivation of transient outward potassium current (Ito), both in a voltage-dependent manner. The averaged inhibition of Ito, evaluated as a change of its time integral, was 23.0 +/- 3.2% at stimulation frequency of 0.1 Hz. As a consequence of slow recovery of Ito from the haloperidol-induced block (time constant 1482 +/- 83 ms), a cumulation of the block up to about 40% appeared at 3.3 Hz.
ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK a Marie NOVÁKOVÁ. Effect of haloperidol on transient outward potassium current in rat ventricular myocytes. \textit{European Journal of Pharmacology}. Amsterdam, The Netherlands: Elsevier Science B.V., 2006, roč.~550, 1-3, s.~15-23. ISSN~0014-2999.
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