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@proceedings{700740,
author = {Šmardová, Lenka and Král, Zdeněk and Huser, Martin and Crha, Igor},
booktitle = {Annals of Oncology},
keywords = {Hodgkins lymphoma; fertility; ABVD; BEACOPP},
language = {cze},
title = {Damage to ovarian functions in young women treated with ABVD and BEACOPP chemotherapy for Hodgkin lymfoma},
year = {2005}
}
TY - CONF
ID - 700740
AU - Šmardová, Lenka - Král, Zdeněk - Huser, Martin - Crha, Igor
PY - 2005
TI - Damage to ovarian functions in young women treated with ABVD and BEACOPP chemotherapy for Hodgkin lymfoma
KW - Hodgkins lymphoma
KW - fertility
KW - ABVD
KW - BEACOPP
N2 - Introduction: Depending on the type of the chemotherapy (CT) administered, premature ovarian failure develops in young women, causing clinical symptoms due to the lack of estrogens, and resulting in subsequent sterility. Objectives: Retrospective analysis of the fertility was made in female pts treated with the BEACOPP or ABVD and MOPP(COPP),ABVD CT. Methods: A total of 16 pts underwent the therapy based on the BEACOPP with baseline (n=6) or escal. doses (n=4), or a combination of 4 cycles of the baseline and escal. BEACOPP (n=6). A total of 32 pts were treated with CT in the past, namely using the ABVD (n=25) or the hybrid MOPP(COPP),ABVD alternating regimen (n=7). Results: 5/16 (31 %) of the pts reported oligomenorrhoea or complete amenorrhoea during the BEACOPP. After 6 months from the end of the therapy, half of the pts (n=8) did not menstruate. The menses disappeared during the ABVD or MOPP (COPP)/ABVD in 6/36 (19 %) of the pts. Conclusions: The BEACOPP poses a risk of early menopause and permanent sterility to young patients owing to the presence of several gonadotoxic agents.
ER -
ŠMARDOVÁ, Lenka, Zdeněk KRÁL, Martin HUSER a Igor CRHA. Damage to ovarian functions in young women treated with ABVD and BEACOPP chemotherapy for Hodgkin lymfoma. In \textit{Annals of Oncology}. 2005. ISSN~0923-7534.
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