PETRLOVÁ, Jitka, David POTĚŠIL, Josef ZEHNÁLEK, Berd SURES, Vojtěch ADAM, Libuše TRNKOVÁ and René KIZEK. Cisplatin electrochemical biosensor. Electrochim. Acta. 2006, vol. 51, No 24, p. 5169-5173. ISSN 0013-4686.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Cisplatin electrochemical biosensor
Name in Czech Elektrochemický biosenzor cisplatiny
Authors PETRLOVÁ, Jitka (203 Czech Republic), David POTĚŠIL (203 Czech Republic), Josef ZEHNÁLEK (203 Czech Republic), Berd SURES (276 Germany), Vojtěch ADAM (203 Czech Republic), Libuše TRNKOVÁ (203 Czech Republic, guarantor) and René KIZEK (203 Czech Republic).
Edition Electrochim. Acta, 2006, 0013-4686.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10405 Electrochemistry
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.955
RIV identification code RIV/00216224:14310/06:00016155
Organization unit Faculty of Science
UT WoS 000239253900023
Keywords in English Cisplatin; electrochemical biosensor
Tags cisplatin, electrochemical biosensor
Changed by Changed by: Ing. Radka Mikelová, Ph.D., učo 176915. Changed: 18/12/2006 12:08.
Abstract
Platinum complexes play an important role in the chemotherapy of various tumour diseases. The aim of this paper was to investigate if a metallothionein (MT) modified hanging mercury drop electrode can be applied as a cisplatin electrochemical biosensor. The modification of the mercury electrode surface by MT and the determination of cisplatin were performed by adsorptive transfer stripping technique and differential pulse voltammetry. The detection limit (3 S/N) of cisplatin ([Pt-II(NH3)(2)Cl-2](0)) calculated from the decrease of CdT peak was about 2.5 pmol in 5 mu l (0.5 mu M) at the interaction time of 400 s. Moreover, we tested the influence of human blood serum as a complex biological matrix on the way of determination of cisplatin. On the basis of the obtained results we estimated that we are able to determine tens of picomoles of cisplatin (5 mu l drop) in the presence of human blood serum.
Abstract (in Czech)
Elektrochemický biosenzor cisplatiny
Links
GP525/04/P132, research and development projectName: Studium obranných mechanismů rostlin při stresu způsobeném těžkými kovy
PrintDisplayed: 6/5/2024 05:18