Immunohistochemical detection of stromal cell-derived factor
(SDF-1) and its CXCR4 receptor in the rat dorsal root ganglia
after nerve ligature

D 2006

Immunohistochemical detection of stromal cell-derived factor (SDF-1) and its CXCR4 receptor in the rat dorsal root ganglia after nerve ligature

PEJCHALOVÁ, Kateřina; Ilona KLUSÁKOVÁ; Ivana SVÍŽENSKÁ a Petr DUBOVÝ

Základní údaje

Originální název

Immunohistochemical detection of stromal cell-derived factor (SDF-1) and its CXCR4 receptor in the rat dorsal root ganglia after nerve ligature

Název česky

Imunohistochemickká detekce SDF-1 a jeho receptoru CXCR4 ve spinálních gangliích potkana po ligatuře nervu

Autoři

PEJCHALOVÁ, Kateřina; Ilona KLUSÁKOVÁ; Ivana SVÍŽENSKÁ a Petr DUBOVÝ

Vydání

3. vyd. France, FENS Abstr. od s. 16-16, 1 s. 2006

Nakladatel

Deux-Ponts

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

chemokine-dorsal root ganglia-neuropathic pain

Štítky

chemokine-dorsal root ganglia-neuropathic pain

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 12. 2006 17:22, prof. RNDr. Petr Dubový, CSc.

Anotace

ORIG CZ

V originále

Stromal cell-derived factor SDF-1 (chemokine ligand CXCL12) belongs to chemokines, small secreted proteins whose effects are mediated by stimulating G-protein-coupled receptors. The chemokine and its receptor CXCR4 are essential for neuro–immune homeostatic functions playing a crucial role not only in the regulation of cellular movement, proliferation, plasticity and survival of the neurons and lymphocytes, but also in pain signaling. The primary sensory neurons of the dorsal root ganglia (DRG) play a key role in neuropathic pain, which has been investigated using rat peripheral nerve injury models including unilateral sciatic and spinal nerve ligature. The goal of present study was to demonstrate immunohistochemical distribution of SDF-1 and CXCR4 in the naive DRG and those following nerve ligatures. The SDF-1 and CXCR4 immunofluorescence found in the DRG affected by unilateral nerve ligature was compared with the contralateral ones removed from operated animals and with those removed from naive rats. The results revealed dynamics in the expression of the chemokine and its receptor suggesting their possible role in the transmission of cellular and molecular changes to the DRG contralateral from the nerve injury.

Česky

SDF-1 a jeho receptor CXCR4 jsou významně zapojeny do homeostatických vztahu mezi nervovou soustavou a imunintním systémem.

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

PEJCHALOVÁ, Kateřina; Ilona KLUSÁKOVÁ; Ivana SVÍŽENSKÁ a Petr DUBOVÝ. Immunohistochemical detection of stromal cell-derived factor (SDF-1) and its CXCR4 receptor in the rat dorsal root ganglia after nerve ligature. In FENS Abstr. 3. vyd. France: Deux-Ponts, 2006, s. 16-16.

@inproceedings{706646,
   author = {Pejchalová, Kateřina and Klusáková, Ilona and Svíženská, Ivana and Dubový, Petr},
   address = {France},
   booktitle = {FENS Abstr.},
   edition = {3},
   keywords = {chemokine-dorsal root ganglia-neuropathic pain},
   language = {eng},
   location = {France},
   pages = {16-16},
   publisher = {Deux-Ponts},
   title = {Immunohistochemical detection of stromal cell-derived factor (SDF-1) and its CXCR4 receptor in the rat dorsal root ganglia after nerve ligature},
   year = {2006}
}

TY  - CONF
ID  - 706646
AU  - Pejchalová, Kateřina - Klusáková, Ilona - Svíženská, Ivana - Dubový, Petr
PY  - 2006
TI  - Immunohistochemical detection of stromal cell-derived factor (SDF-1) and its CXCR4 receptor in the rat dorsal root ganglia after nerve ligature
PB  - Deux-Ponts
CY  - France
KW  - chemokine-dorsal root ganglia-neuropathic pain
N2  - Stromal cell-derived factor SDF-1 (chemokine ligand CXCL12) belongs to chemokines, small secreted proteins whose effects are mediated by stimulating G-protein-coupled receptors. The chemokine and its receptor CXCR4 are essential for neuro–immune homeostatic functions playing a crucial role not only in the regulation of cellular movement, proliferation, plasticity and survival of the neurons and lymphocytes, but also in pain signaling. The primary sensory neurons of the dorsal root ganglia (DRG) play a key role in neuropathic pain, which has been investigated using rat peripheral nerve injury models including unilateral sciatic and spinal nerve ligature. The goal of present study was to demonstrate immunohistochemical distribution of SDF-1 and CXCR4 in the naive DRG and those following nerve ligatures. The SDF-1 and CXCR4 immunofluorescence found in the DRG affected by unilateral nerve ligature was compared with the contralateral ones removed from operated animals and with those removed from naive rats. The results revealed dynamics in the expression of the chemokine and its receptor suggesting their possible role in the transmission of cellular and molecular changes to the DRG contralateral from the nerve injury.
ER  -

PEJCHALOVÁ, Kateřina; Ilona KLUSÁKOVÁ; Ivana SVÍŽENSKÁ a Petr DUBOVÝ. Immunohistochemical detection of stromal cell-derived factor (SDF-1) and its CXCR4 receptor in the rat dorsal root ganglia after nerve ligature. In \textit{FENS Abstr.}. 3. vyd. France: Deux-Ponts, 2006, s.~16-16.

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