Experimental Models of Peripheral Neuropathic Pain - An
Anatomical View

D 2006

Experimental Models of Peripheral Neuropathic Pain - An Anatomical View

KLUSÁKOVÁ, Ilona; Petr DUBOVÝ; Ivana SVÍŽENSKÁ a Lumír TRENČANSKÝ

Základní údaje

Originální název

Experimental Models of Peripheral Neuropathic Pain - An Anatomical View

Název česky

Experimentální modely periferní neuropatické bolesti - anatomický pohled

Autoři

KLUSÁKOVÁ, Ilona; Petr DUBOVÝ; Ivana SVÍŽENSKÁ a Lumír TRENČANSKÝ

Vydání

Praha, Morpholgy 2006, od s. 95-95, 1 s. 2006

Nakladatel

UK Praha

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

dorsal root ganglia - neuropathic pain models

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 12. 2006 13:01, prof. RNDr. Petr Dubový, CSc.

Anotace

ORIG CZ

V originále

The neuropathic pain (NP) is initiated or caused by a primary lesion or dysfunction in the nervous system. In order to identify novel therapeutics and to design compounds for clinical use, it is important to understand the underlying NP mechanisms. To explore mechanisms of the peripheral NP, several experimental models have been developed. The goal of our paper is to review models of the peripheral NP in respect of affected dorsal root ganglia (DRG) neurons. The models differ in a form and location of the peripheral nerve injury. The former includes the nerve transection related with total axonal disconnection (axotomy) and loose or tight ligations that mimic only a partial damage of the nerves. Based on the location of nerve injury, the models can be divided into two major groups. The first comprises models of the peripheral nerve injury, either total nerve transection (axotomy) or partial nerve injury (PNI). The most used approach of PNI is i/ partial ligature of the sciatic nerve, ii/ chronic constriction of the sciatic nerve, iii/ tight ligation of L5/L6 spinal nerves and iv/ spared nerve injury with several modifications. The second group of models includes an injury of both dorsal and ventral roots of the spinal nerves. All experimental models result in behavioral changes measured as thermal hyperalgesia and mechanical allodynia. From anatomical point of view, the different experimental models affect the DRG neurons of various ranges that could result in diverse mechanisms of the peripheral NP.

Česky

Byl proveden přehled modelu neuropatické bolesti a analyzovány jejich anatomické vlastnosti v kontextu fyziologických projevů.

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

KLUSÁKOVÁ, Ilona; Petr DUBOVÝ; Ivana SVÍŽENSKÁ a Lumír TRENČANSKÝ. Experimental Models of Peripheral Neuropathic Pain - An Anatomical View. In Morpholgy 2006. Praha: UK Praha, 2006, s. 95-95.

@inproceedings{707061,
   author = {Klusáková, Ilona and Dubový, Petr and Svíženská, Ivana and Trenčanský, Lumír},
   address = {Praha},
   booktitle = {Morpholgy 2006},
   keywords = {dorsal root ganglia - neuropathic pain models},
   language = {eng},
   location = {Praha},
   pages = {95-95},
   publisher = {UK Praha},
   title = {Experimental Models of Peripheral Neuropathic Pain - An Anatomical View},
   year = {2006}
}

TY  - CONF
ID  - 707061
AU  - Klusáková, Ilona - Dubový, Petr - Svíženská, Ivana - Trenčanský, Lumír
PY  - 2006
TI  - Experimental Models of Peripheral Neuropathic Pain - An Anatomical View
PB  - UK Praha
CY  - Praha
KW  - dorsal root ganglia - neuropathic pain models
N2  - The neuropathic pain (NP) is initiated or caused by a primary lesion or dysfunction in the nervous system. In order to identify novel therapeutics and to design compounds for clinical use, it is important to understand the underlying NP mechanisms. To explore mechanisms of the peripheral NP, several experimental models have been developed. The goal of our paper is to review models of the peripheral NP in respect of affected dorsal root ganglia (DRG) neurons. The models differ in a form and location of the peripheral nerve injury. The former includes the nerve transection related with total axonal disconnection (axotomy) and loose or tight ligations that mimic only a partial damage of the nerves. Based on the location of nerve injury, the models can be divided into two major groups. The first comprises models of the peripheral nerve injury, either total nerve transection (axotomy) or partial nerve injury (PNI). The most used approach of PNI is i/ partial ligature of the sciatic nerve, ii/ chronic constriction of the sciatic nerve, iii/ tight ligation of L5/L6 spinal nerves and iv/ spared nerve injury with several modifications. The second group of models includes an injury of both dorsal and ventral roots of the spinal nerves. All experimental models result in behavioral changes measured as thermal hyperalgesia and mechanical allodynia. From anatomical point of view, the different experimental models affect the DRG neurons of various ranges that could result in diverse mechanisms of the peripheral NP.
ER  -

KLUSÁKOVÁ, Ilona; Petr DUBOVÝ; Ivana SVÍŽENSKÁ a Lumír TRENČANSKÝ. Experimental Models of Peripheral Neuropathic Pain - An Anatomical View. In \textit{Morpholgy 2006}. Praha: UK Praha, 2006, s.~95-95.

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