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@proceedings{712443,
author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Šimurdová, Milena and Šimurda, Jiří},
booktitle = {Scripta Medica},
keywords = {ajmaline;action potential;ionic currents;rat;patch clamp},
language = {eng},
title = {Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes},
year = {2005}
}
TY - CONF
ID - 712443
AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Šimurdová, Milena - Šimurda, Jiří
PY - 2005
TI - Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes
KW - ajmaline;action potential;ionic currents;rat;patch clamp
N2 - Ajmaline decreased the upstroke velocity of action potential and its amplitude, very likely by inhibition of sodium current INa. The observed prolongation of action potential was probably related to the inhibition of transient outward potassium current Ito, the main repolarizing current in rat. This effect predominates over the opposite effect of the inhibition of calcium current ICaL, partly because of lower IC50.
ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Effect of ajmaline on course of action potential and ionic membrane currents in rat ventricular myocytes. In \textit{Scripta Medica}. 2005. ISSN~1211-3395.
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