Toxicological aspects of flavonoid interaction with
biomacromolecules

J 2006

Toxicological aspects of flavonoid interaction with biomacromolecules

HODEK, P.; Pavel HANUŠTIAK; J. KŘÍŽKOVÁ; Radka MIKELOVÁ; Soňa KŘÍŽKOVÁ et. al.

Základní údaje

Originální název

Toxicological aspects of flavonoid interaction with biomacromolecules

Název česky

Toxikologické aspekty interakcí flavonoidů s biomakromolekulami

Autoři

HODEK, P.; Pavel HANUŠTIAK; J. KŘÍŽKOVÁ; Radka MIKELOVÁ; Soňa KŘÍŽKOVÁ; M. STIBOROVÁ; Libuše TRNKOVÁ; Aleš HORNA; Miroslava BEKLOVÁ a René KIZEK

Vydání

Neuroendocrinol. Lett. 2006, 0172-780X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10405 Electrochemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.924

Kód RIV

RIV/00216224:14310/06:00015538

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000245442600004

Klíčová slova anglicky

Flavonoids; interactions; biomacromolecules

Štítky

biomacromolecules, flavonoids, interactions

Změněno: 14. 2. 2007 16:21, Ing. Radka Mikelová, Ph.D.

Anotace

ORIG CZ

V originále

Flavonoids are widely accepted as health promoting phytochemicals, however, some flavonoids show ability of direct interaction with DNA and/or enhance carcinogen activation into DNA modifying agents. Thus, their potential harmful effect on the human body should be examined in detail. METHODS: Direct interaction of flavonoids (quercetin, rutin) with DNA was examined using square wave voltammetry on carbon paste electrode. Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody. RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver. Moreover, synthetic beta-naphthoflavone and naturally occurring chrysin, quercetin and diosmin induced CYP1A1 in both tissues. The oxidation signals of guanine and adenine in the DNA molecule were decreased in the presence of flavonoids.

Česky

Toxikologické aspekty interakcí flavonoidů s biomakromolekulami

Návaznosti

GP525/04/P132, projekt VaV

Název: Studium obranných mechanismů rostlin při stresu způsobeném těžkými kovy

IAA100040602, projekt VaV

Název: Nové přístupy v elektrochemické analýze nukleových kyselin a oligonukleotidů zaměřené na ultrasensitivní mikrodetekci DNA a detekci DNA hybridizace.

Investor: Akademie věd ČR, Nové přístupy v elektrochemické analýze nukleových kyselin a oligonukleotidů zaměřené na ultrasensitivní mikrodetekci DNA a detekci DNA hybridizace

Citovat

HODEK, P.; Pavel HANUŠTIAK; J. KŘÍŽKOVÁ; Radka MIKELOVÁ; Soňa KŘÍŽKOVÁ; M. STIBOROVÁ; Libuše TRNKOVÁ; Aleš HORNA; Miroslava BEKLOVÁ a René KIZEK. Toxicological aspects of flavonoid interaction with biomacromolecules. Neuroendocrinol. Lett. 2006, roč. 27, suppl2, s. 14-17. ISSN 0172-780X.

@article{712560,
   author = {Hodek, P. and Hanuštiak, Pavel and Křížková, J. and Mikelová, Radka and Křížková, Soňa and Stiborová, M. and Trnková, Libuše and Horna, Aleš and Beklová, Miroslava and Kizek, René},
   article_number = {suppl2},
   keywords = {Flavonoids; interactions; biomacromolecules},
   language = {eng},
   issn = {0172-780X},
   journal = {Neuroendocrinol. Lett.},
   title = {Toxicological aspects of flavonoid interaction with biomacromolecules},
   volume = {27},
   year = {2006}
}

TY  - JOUR
ID  - 712560
AU  - Hodek, P. - Hanuštiak, Pavel - Křížková, J. - Mikelová, Radka - Křížková, Soňa - Stiborová, M. - Trnková, Libuše - Horna, Aleš - Beklová, Miroslava - Kizek, René
PY  - 2006
TI  - Toxicological aspects of flavonoid interaction with biomacromolecules
JF  - Neuroendocrinol. Lett.
VL  - 27
IS  - suppl2
SP  - 14-17
EP  - 14-17
SN  - 0172780X
KW  - Flavonoids
KW  - interactions
KW  - biomacromolecules
N2  - Flavonoids are widely accepted as health promoting phytochemicals, however, some flavonoids show ability of direct interaction with DNA and/or enhance carcinogen activation into DNA modifying agents. Thus, their potential harmful effect on the human body should be examined in detail. METHODS: Direct interaction of flavonoids (quercetin, rutin) with DNA was examined using square wave voltammetry on carbon paste electrode. Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody. RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver. Moreover, synthetic beta-naphthoflavone and naturally occurring chrysin, quercetin and diosmin induced CYP1A1 in both tissues. The oxidation signals of guanine and adenine in the DNA molecule were decreased in the presence of flavonoids.
ER  -

HODEK, P.; Pavel HANUŠTIAK; J. KŘÍŽKOVÁ; Radka MIKELOVÁ; Soňa KŘÍŽKOVÁ; M. STIBOROVÁ; Libuše TRNKOVÁ; Aleš HORNA; Miroslava BEKLOVÁ a René KIZEK. Toxicological aspects of flavonoid interaction with biomacromolecules. \textit{Neuroendocrinol. Lett.}. 2006, roč.~27, suppl2, s.~14-17. ISSN~0172-780X.

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