ZHANG, Jie, Jiří KONEČNÝ, Zdeněk GLATZ, Jos HOOGMARTENS a Ann VAN SCHEPDAEL. Review: Application of capillary electrophoresis in drug metabolism studies. Current Analytical Chemistry. USA: BENTHAM SCIENCE PUBL LTD, 2007, roč. 3, č. 3, s. 197-217. ISSN 1573-4110. |
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@article{719245, author = {Zhang, Jie and Konečný, Jiří and Glatz, Zdeněk and Hoogmartens, Jos and Van Schepdael, Ann}, article_location = {USA}, article_number = {3}, keywords = {capillary electrophoresis; drug metabolism}, language = {eng}, issn = {1573-4110}, journal = {Current Analytical Chemistry}, title = {Review: Application of capillary electrophoresis in drug metabolism studies}, volume = {3}, year = {2007} }
TY - JOUR ID - 719245 AU - Zhang, Jie - Konečný, Jiří - Glatz, Zdeněk - Hoogmartens, Jos - Van Schepdael, Ann PY - 2007 TI - Review: Application of capillary electrophoresis in drug metabolism studies JF - Current Analytical Chemistry VL - 3 IS - 3 SP - 197-217 EP - 197-217 PB - BENTHAM SCIENCE PUBL LTD SN - 15734110 KW - capillary electrophoresis KW - drug metabolism N2 - Capillary electrophoresis (CE) has been increasingly employed for the separation of pharmaceutical agents and drugs. This has arisen from the complementary mode of separation afforded by CE when compared to high performance liquid chromatography (HPLC). Qualities of CE such as high efficiency of separation, short analysis time, remarkably low injection volume and a variety of detection systems have facilitated acceptance of this technology. Since different drug metabolite enantiomers are formed in many metabolic pathways, the other indispensable advantage of CE over HPLC is the possibility of chiral separation without the need of special expensive columns. Recent advances in automated systems have made CE even more popular. The focus of this paper is to review recent studies and advances (mainly from 2000) of drug metabolism by using CE. The review is divided into two parts: (i) principles of CE separation of drugs and their metabolites and (ii) application of CE in drug metabolism studies. The first part introduces sample preparation, separation and detection modes involved in CE drug metabolism studies. To provide a deeper insight into the achievements, distinction between drug metabolism analysis in vivo and in vitro is made in the second part. Reported methods are discussed and summarized. ER -
ZHANG, Jie, Jiří KONEČNÝ, Zdeněk GLATZ, Jos HOOGMARTENS a Ann VAN SCHEPDAEL. Review: Application of capillary electrophoresis in drug metabolism studies. \textit{Current Analytical Chemistry}. USA: BENTHAM SCIENCE PUBL LTD, 2007, roč.~3, č.~3, s.~197-217. ISSN~1573-4110.
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