The morphology changes in rats kidney after administration of
Amphotericin B colloidal dispersion and conventional
Amphotericin B deoxycholate

D 2003

The morphology changes in rats kidney after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate

KREJČÍŘOVÁ, Lenka; Drahomír HORKÝ; Irena LAUSCHOVÁ; Michael DOUBEK; Jiří MAYER et al.

Základní údaje

Originální název

The morphology changes in rats kidney after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate

Název česky

Morfologické změny ledvin potkana po podání Amphotericinu B a konvenčního Amphotericinu B deoxycholátu

Autoři

KREJČÍŘOVÁ, Lenka; Drahomír HORKÝ; Irena LAUSCHOVÁ; Michael DOUBEK; Jiří MAYER a Jaromír DOUBEK

Vydání

Hradec Králové, Sborník abstrakt41.symposia české anatomické společnosti s mezinárodní účastí, od s. 33-33, 1 s. 2003

Nakladatel

Reklamní agentura Hradec Králové

Další údaje

Typ výsledku

Stať ve sborníku

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

ISBN

80-239-1412-X

Klíčová slova anglicky

kidney rat amphotericin B deoxycholate amphotericin B colloidal dispersion

Změněno: 14. 9. 2007 14:29, MUDr. Lenka Krejčířová, Ph.D.

Anotace

ORIG CZ

V originále

Amphotericin B (AmB) is used in clinics despite its nephrotoxicity because it remains one of the most efficacious agents currently available for treatment of systemic fungal infections. Amphotericin B colloidal dispersion (ABCD) in addition to the conventional AmB deoxycholate is used in clinics. The goal of our study was to compare the morphology changes of a nephron in the rat after administration of ABCD and AmB. Preliminary clinic study did not show significant differences. Laboratory male rats (pathogen – free, source Anlab, Pratur, Czech Republic), 265-350 g of weight, were used as an experimental model. Two groups of animals were established: group 1 rats were treated with AmB deoxycholate ( Amphotericin B Squibb , Bristol-Myers Squibb,mg/kg of body weight daily for period of 14 days), in group 2 were animals treated with ABCD ( Amphocil, Torrex Pharma, 12 mg/kg of body weight daily for a period of 14 days). Rats were sacrificed and the kidneys were processed for light and elektron microscopy. It was executed also the morphometric study.

Česky

Oba léky poškozují po delší aplikaci ledvinnou tkáň. Domníváme se, že nekroticky.Do budoucna by bylo vhodné rozpracovat problematiku ireversibility těchto změn z hlediska dlouhodobého podávání AmB a ABCD a možnost snížení toxicity obou látek suplementací nefroprotektivy.

Návaznosti

NL6514, projekt VaV

Název: Jednoduché nefroprotektivní postupy v profylaxi nefrotoxicity konvenčního amfotericinu B u onkologických pacientů

Investor: Ministerstvo zdravotnictví ČR, Jednoduché nefroprotektivní postupy v profylaxi nefrotoxicity konvenčního amfotericinu B u onkologických pacientů

Citovat

KREJČÍŘOVÁ, Lenka; Drahomír HORKÝ; Irena LAUSCHOVÁ; Michael DOUBEK; Jiří MAYER a Jaromír DOUBEK. The morphology changes in rats kidney after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate. In Sborník abstrakt41.symposia české anatomické společnosti s mezinárodní účastí. Hradec Králové: Reklamní agentura Hradec Králové, 2003, s. 33-33. ISBN 80-239-1412-X.

@inproceedings{724988,
   author = {Krejčířová, Lenka and Horký, Drahomír and Lauschová, Irena and Doubek, Michael and Mayer, Jiří and Doubek, Jaromír},
   address = {Hradec Králové},
   booktitle = {Sborník abstrakt41.symposia české anatomické společnosti s mezinárodní účastí},
   keywords = {kidney rat amphotericin B deoxycholate amphotericin B colloidal dispersion},
   location = {Hradec Králové},
   isbn = {80-239-1412-X},
   pages = {33-33},
   publisher = {Reklamní agentura Hradec Králové},
   title = {The morphology changes in rats kidney after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate},
   year = {2003}
}

TY  - CONF
ID  - 724988
AU  - Krejčířová, Lenka - Horký, Drahomír - Lauschová, Irena - Doubek, Michael - Mayer, Jiří - Doubek, Jaromír
PY  - 2003
TI  - The morphology changes in rats kidney after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate
PB  - Reklamní agentura Hradec Králové
CY  - Hradec Králové
SN  - 802391412X
KW  - kidney rat amphotericin B deoxycholate amphotericin B colloidal dispersion
N2  - Amphotericin B (AmB) is used in clinics despite its nephrotoxicity because it remains one of the most efficacious agents currently available for treatment of systemic fungal infections. Amphotericin B colloidal dispersion (ABCD) in addition to the conventional AmB deoxycholate is used in clinics. The goal of our study was to compare the morphology changes of a nephron in the rat after administration of ABCD and AmB. Preliminary clinic study did not show significant differences. Laboratory male rats (pathogen – free, source Anlab, Pratur, Czech Republic), 265-350 g of weight, were used as an experimental model. Two groups of animals were established: group 1 rats were treated with AmB deoxycholate ( Amphotericin B Squibb , Bristol-Myers Squibb,mg/kg of body weight daily for period of 14 days), in group 2 were animals treated with ABCD ( Amphocil, Torrex Pharma, 12 mg/kg of body weight daily for a period of 14 days). Rats were sacrificed and the kidneys were processed for light and elektron microscopy. It was executed also the morphometric study.
ER  -

KREJČÍŘOVÁ, Lenka; Drahomír HORKÝ; Irena LAUSCHOVÁ; Michael DOUBEK; Jiří MAYER a Jaromír DOUBEK. The morphology changes in rats kidney after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate. In \textit{Sborník abstrakt41.symposia české anatomické společnosti s mezinárodní účastí}. Hradec Králové: Reklamní agentura Hradec Králové, 2003, s.~33-33. ISBN~80-239-1412-X.

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