CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD
PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING
AUTOLOGOUS STEM CELL TRANSPLANTATION

D 2007

CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION

GREŠLIKOVÁ, Henrieta; Petr KUGLÍK; Hana FILKOVÁ; Alexandra OLTOVÁ; Zdeněk ADAM et al.

Základní údaje

Originální název

CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION

Název česky

Vzťah medzi chromozómovými abnormalitami a štandardnými prognostickými faktormi u pacientov s mnohopočetným myelomom.

Autoři

GREŠLIKOVÁ, Henrieta; Petr KUGLÍK; Hana FILKOVÁ; Alexandra OLTOVÁ; Zdeněk ADAM; Andrea KŘIVANOVÁ; Luděk POUR; Jana SMEJKALOVÁ; Marta KREJČÍ a Roman HÁJEK

Vydání

Volume 21, Supplement 1. Edinburgh, Blood reviews, od s. 85-85, 1 s. 2007

Nakladatel

Churchill Livingstone

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

Genetika a molekulární biologie

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.922

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/07:00019111

Organizační jednotka

Lékařská fakulta

ISSN

UT WoS

000249533100073

Klíčová slova anglicky

multiple myeloma; cIg FISH; chromosomal changes;autologous stem cell transplantation

Štítky

autologous stem cell transplantation, chromosomal changes, cIg FISH, multiple myeloma

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 6. 2008 10:10, RNDr. Henrieta Grešliková

Anotace

ORIG CZ

V originále

Introduction Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. The aim of this study was to determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Materials and Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17,5 months, median age 57 years (39-67), DS stadium: stage I 7,1%, II 24,3%, III 68,6%; A/B - 84.3%/15.7%. Results Overall response (OR) rate after AT was 78,5% including 13% CR, 27% VGPR and 38,5% PR. Median of time to progression (TTP) was 17,5 (0,4-41,4) months. Median of overall survival (OS) was 22,9 (0,4-48,5) months. The aberration of the chromosome 13 was found in 53,5% (37/69), IGH rearrangements in 57% (37/66), t(11;14) in 16,6% (11/66), t(4;14) in 23% (15/66) and deletion of 17p13 in 17% (9/53) pts. We have correlated standard prognostic factors (MIG, LD, B2M, Hb, CRP, Ca, albumin), TTP, progression free survival (PFS), duration of response (DOR) and OS with the occurrence of the mentioned aberrations. Higher CRP, lower albumin and lower Ca concentrations were detected in patients with aberration of chromosome 13. We have observed trend for shorter TTP in patients with deletion of 17p13 and then in pts without this deletion (18,5 vs.21,9 months; p=0,287). As for this aberration we have found no significant difference when compared incidence of each chromosomal aberration for TTP, DOR, PFS and OS. Conclusion We have analysed data of the homogenous group of patients undergoing autologous transplantation in the CMG trial of Czech Myeloma Group. Based on the results we conclude that patients with deletion of 13q14 have higher CRP, lower albumin and lower Ca concentration.

Česky

Zaoberali sme sa koreláciou medzi chromozómovými aberáciami a štandardnými prognostickými faktormi u pacientov s mnohopočetným myelomom liečných konvenčnou chemoterapiou.

Návaznosti

NR8183, projekt VaV

Název: Molekulárně-cytogenetická analýza značených plazmatických buněk a prognostický význam klonálních chromosomových aberací u mnohočetného myelomu

Citovat

GREŠLIKOVÁ, Henrieta; Petr KUGLÍK; Hana FILKOVÁ; Alexandra OLTOVÁ; Zdeněk ADAM; Andrea KŘIVANOVÁ; Luděk POUR; Jana SMEJKALOVÁ; Marta KREJČÍ a Roman HÁJEK. CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION. In Blood reviews. Volume 21, Supplement 1. Edinburgh: Churchill Livingstone, 2007, s. 85-85. ISSN 0268-960X.

@inproceedings{727211,
   author = {Grešliková, Henrieta and Kuglík, Petr and Filková, Hana and Oltová, Alexandra and Adam, Zdeněk and Křivanová, Andrea and Pour, Luděk and Smejkalová, Jana and Krejčí, Marta and Hájek, Roman},
   address = {Edinburgh},
   booktitle = {Blood reviews},
   edition = {Volume 21, Supplement 1},
   keywords = {multiple myeloma; cIg FISH; chromosomal changes;autologous stem cell transplantation},
   language = {eng},
   location = {Edinburgh},
   pages = {85-85},
   publisher = {Churchill Livingstone},
   title = {CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION},
   year = {2007}
}

TY  - CONF
ID  - 727211
AU  - Grešliková, Henrieta - Kuglík, Petr - Filková, Hana - Oltová, Alexandra - Adam, Zdeněk - Křivanová, Andrea - Pour, Luděk - Smejkalová, Jana - Krejčí, Marta - Hájek, Roman
PY  - 2007
TI  - CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION
PB  - Churchill Livingstone
CY  - Edinburgh
KW  - multiple myeloma
KW  - cIg FISH
KW  - chromosomal changes;autologous stem cell transplantation
N2  - Introduction Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. The aim of this study was to determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Materials and Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17,5 months, median age 57 years (39-67), DS stadium: stage I 7,1%, II 24,3%, III 68,6%; A/B - 84.3%/15.7%. Results Overall response (OR) rate after AT was 78,5% including 13% CR, 27% VGPR and 38,5% PR. Median of time to progression (TTP) was 17,5 (0,4-41,4) months. Median of overall survival (OS) was 22,9 (0,4-48,5) months. The aberration of the chromosome 13 was found in 53,5% (37/69), IGH rearrangements in 57% (37/66), t(11;14) in 16,6% (11/66), t(4;14) in 23% (15/66) and deletion of 17p13 in 17% (9/53) pts. We have correlated standard prognostic factors (MIG, LD, B2M, Hb, CRP, Ca, albumin), TTP, progression free survival (PFS), duration of response (DOR) and OS with the occurrence of the mentioned aberrations. Higher CRP, lower albumin and lower Ca concentrations were detected in patients with aberration of chromosome 13. We have observed trend for shorter TTP in patients with deletion of 17p13 and then in pts without this deletion (18,5 vs.21,9 months; p=0,287). As for this aberration we have found no significant difference when compared incidence of each chromosomal aberration for TTP, DOR, PFS and OS. Conclusion We have analysed data of the homogenous group of patients undergoing autologous transplantation in the CMG trial of Czech Myeloma Group. Based on the results we conclude that patients with deletion of 13q14 have higher CRP, lower albumin and lower Ca concentration.
ER  -

GREŠLIKOVÁ, Henrieta; Petr KUGLÍK; Hana FILKOVÁ; Alexandra OLTOVÁ; Zdeněk ADAM; Andrea KŘIVANOVÁ; Luděk POUR; Jana SMEJKALOVÁ; Marta KREJČÍ a Roman HÁJEK. CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION. In \textit{Blood reviews}. Volume 21, Supplement 1. Edinburgh: Churchill Livingstone, 2007, s.~85-85. ISSN~0268-960X.

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