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@proceedings{746324,
author = {Tučková, Lucie and Dubový, Petr and Jančálek, Radim and Svíženská, Ivana and Klusáková, Ilona},
booktitle = {41. sjezd Slovenské anatomické společnosti a 41. Lojdovo sympozium „Progress in basic, applied and diagnostic histochemistry“},
keywords = {macrophages; ED-1; dorsal root ganglia; peripheral nerve injury; Wallerian degeneration},
language = {eng},
title = {An increased invasion of ED-1+ cells into ipsi- and contralateral DRG following sciatic nerve ligature and ventral root transection},
year = {2007}
}
TY - CONF
ID - 746324
AU - Tučková, Lucie - Dubový, Petr - Jančálek, Radim - Svíženská, Ivana - Klusáková, Ilona
PY - 2007
TI - An increased invasion of ED-1+ cells into ipsi- and contralateral DRG following sciatic nerve ligature and ventral root transection
KW - macrophages
KW - ED-1
KW - dorsal root ganglia
KW - peripheral nerve injury
KW - Wallerian degeneration
N2 - Macrophages increase in number in dorsal root ganglion (DRG) following nerve injury, and their activities are referred as to induce neuropathic pain. Macrophages exhibiting ED-1+ immunostaining were examined quantitatively in lumbar ipsi- (iDRG) and contralateral (cDRG) ganglia of naive rats and those following nerve injury. An amount of ED-1+ macrophages were found in naive DRG without intimate location to the neuronal bodies. ED-1+ was significantly enlarged and located close to neuronal bodies in iDRG 2 and 4 weeks from sciatic nerve ligature. cDRG also displayed an increase amount of ED-1+ macrophages, predominantly following 4 weeks. Ventral root transection resulted in an increased amount of ED-1+ cells in both i- and cDRG. However, the enlargement was similar on both sides after 2 weeks, but greater elevation was observed only in iDRG after 4 weeks. The results indicate that nerve injury stimulated invasion of ED-1+ macrophages predominantly into iDRG, and later to cDRG, and suggested that Wallerian degeneration produces signals for invasion of macrophages to cDRG.
ER -
TUČKOVÁ, Lucie, Petr DUBOVÝ, Radim JANČÁLEK, Ivana SVÍŽENSKÁ a Ilona KLUSÁKOVÁ. An increased invasion of ED-1+ cells into ipsi- and contralateral DRG following sciatic nerve ligature and ventral root transection. In \textit{41. sjezd Slovenské anatomické společnosti a 41. Lojdovo sympozium „Progress in basic, applied and diagnostic histochemistry“}. 2007.
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