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@article{747018,
author = {Bareš, Martin and Kaňovský, Petr and Rektor, Ivan},
article_location = {Oxford},
article_number = {8},
keywords = {Parkinson disease- paired TMS- L-DOPA- intracortical excitability},
language = {eng},
issn = {1353-8020},
journal = {Parkinsonism and Related Disorders},
title = {Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study.},
volume = {13},
year = {2007}
}
TY - JOUR
ID - 747018
AU - Bareš, Martin - Kaňovský, Petr - Rektor, Ivan
PY - 2007
TI - Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study.
JF - Parkinsonism and Related Disorders
VL - 13
IS - 8
SP - 489-494
EP - 489-494
PB - Elsevier
SN - 13538020
KW - Parkinson disease- paired TMS- L-DOPA- intracortical excitability
N2 - We were interested to know if chronic l-DOPA treatment in Parkinson's disease (PD) patients could restore impairment of the intracortical excitability, when this difference could occur, and if it was related to the total daily dose of l-DOPA. Twelve patients with early PD were studied using paired transcranial magnetic stimulation before the administration of l-DOPA, and then after 3, 6, and 12 months of l-DOPA treatment. The level of disturbed intracortical excitability strongly correlated with the total daily dose of l-DOPA. The level of cortical excitability in PD patients seems to be indirectly related to the nigro-striatal functioning.
ER -
BAREŠ, Martin, Petr KAŇOVSKÝ a Ivan REKTOR. Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study. \textit{Parkinsonism and Related Disorders}. Oxford: Elsevier, roč.~13, č.~8, s.~489-494. ISSN~1353-8020. 2007.
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