BAREŠ, Martin, Petr KAŇOVSKÝ and Ivan REKTOR. Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study. Parkinsonism and Related Disorders. Oxford: Elsevier, 2007, vol. 13, No 8, p. 489-494. ISSN 1353-8020. |
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@article{747018, author = {Bareš, Martin and Kaňovský, Petr and Rektor, Ivan}, article_location = {Oxford}, article_number = {8}, keywords = {Parkinson disease- paired TMS- L-DOPA- intracortical excitability}, language = {eng}, issn = {1353-8020}, journal = {Parkinsonism and Related Disorders}, title = {Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study.}, volume = {13}, year = {2007} }
TY - JOUR ID - 747018 AU - Bareš, Martin - Kaňovský, Petr - Rektor, Ivan PY - 2007 TI - Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study. JF - Parkinsonism and Related Disorders VL - 13 IS - 8 SP - 489-494 EP - 489-494 PB - Elsevier SN - 13538020 KW - Parkinson disease- paired TMS- L-DOPA- intracortical excitability N2 - We were interested to know if chronic l-DOPA treatment in Parkinson's disease (PD) patients could restore impairment of the intracortical excitability, when this difference could occur, and if it was related to the total daily dose of l-DOPA. Twelve patients with early PD were studied using paired transcranial magnetic stimulation before the administration of l-DOPA, and then after 3, 6, and 12 months of l-DOPA treatment. The level of disturbed intracortical excitability strongly correlated with the total daily dose of l-DOPA. The level of cortical excitability in PD patients seems to be indirectly related to the nigro-striatal functioning. ER -
BAREŠ, Martin, Petr KAŇOVSKÝ and Ivan REKTOR. Disturbed intracortical excitability in early Parkinson's disease is l-DOPA dose related: A prospective 12-month paired TMS study. \textit{Parkinsonism and Related Disorders}. Oxford: Elsevier, 2007, vol.~13, No~8, p.~489-494. ISSN~1353-8020.
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