Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha
production in antigen-presenting cells from patients with
X-linked agammaglobulinemia

J 2007

Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia

SOCHOROVÁ, Klára; R. HORVÁTH; D. ROZKOVÁ; Jiří LITZMAN; Jiřina BARTŮŇKOVÁ et al.

Základní údaje

Originální název

Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia

Název česky

Nedostatečná produkce IL-6 a TNF alfa po stimulaci TLR-8 antigen prezentujících buněk u nemocných s X-vázanou agamaglobulinémií

Autoři

SOCHOROVÁ, Klára; R. HORVÁTH; D. ROZKOVÁ; Jiří LITZMAN; Jiřina BARTŮŇKOVÁ; Anna ŠEDIVÁ a Radek SPÍŠEK

Vydání

Blood, 2007, 0006-4971

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 10.896

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/07:00032820

Organizační jednotka

Lékařská fakulta

UT WoS

000245004700045

Klíčová slova anglicky

Toll-like receptor; Brutons tyrosine kinase; antigen-presenting cells

Štítky

antigen-presenting cells, Brutons tyrosine kinase, toll-like receptor

Příznaky

Recenzováno

Změněno: 2. 4. 2010 08:04, prof. MUDr. Jiří Litzman, CSc.

Anotace

ORIG CZ

V originále

The critical role of Bruton tyrosine kinase (Btk) in B cells has been documented by the block of B-cell development in X-linked agammaglobulinemia (XLA). Less is known about Btk function in myeloid cells. Several pieces of evidence indicate that Btk is a component of Toll-like receptor (TLR) signaling. We analyzed whether Btk deficiency in XLA is associated with an impaired dendritic cell (DC) compartment or defective TLR signaling. We analyzed the expression of TLRs 1 to 9 on myeloid DCs generated from XLA patients and evaluated their response to activation by specific TLR agonists. We show that XLA patients have normal numbers of circulating DCs. Btk-deficient DCs have no defect in response to stimulation of TLRs 1/2, 2/6, 3, 4, and 5 but display a profound impairment of IL-6 and TNF-alpha production in response to stimulation by TLR-8 cognate agonist, ssRNA. These findings may provide an explanation for the susceptibility to enteroviral infections in XLA patients.

Česky

Produkce IL-6 a TNF alfa po stimulaci TLR-8 antigen prezentujících buněk u nemocných s X-vázanou agamaglobulinémií je nedostatečná.

Citovat

SOCHOROVÁ, Klára; R. HORVÁTH; D. ROZKOVÁ; Jiří LITZMAN; Jiřina BARTŮŇKOVÁ; Anna ŠEDIVÁ a Radek SPÍŠEK. Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia. Blood. 2007, roč. 109, č. 6, s. 2553-2556. ISSN 0006-4971.

@article{748682,
   author = {Sochorová, Klára and Horváth, R. and Rozková, D. and Litzman, Jiří and Bartůňková, Jiřina and Šedivá, Anna and Spíšek, Radek},
   article_number = {6},
   keywords = {Toll-like receptor; Brutons tyrosine kinase; antigen-presenting cells},
   language = {eng},
   issn = {0006-4971},
   journal = {Blood},
   title = {Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia},
   volume = {109},
   year = {2007}
}

TY  - JOUR
ID  - 748682
AU  - Sochorová, Klára - Horváth, R. - Rozková, D. - Litzman, Jiří - Bartůňková, Jiřina - Šedivá, Anna - Spíšek, Radek
PY  - 2007
TI  - Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia
JF  - Blood
VL  - 109
IS  - 6
SP  - 2553-2556
EP  - 2553-2556
SN  - 00064971
KW  - Toll-like receptor
KW  - Brutons tyrosine kinase
KW  - antigen-presenting cells
N2  - The critical role of Bruton tyrosine kinase (Btk) in B cells has been documented by the block of B-cell development in X-linked agammaglobulinemia (XLA). Less is known about Btk function in myeloid cells. Several pieces of evidence indicate that Btk is a component of Toll-like receptor (TLR) signaling. We analyzed whether Btk deficiency in XLA is associated with an impaired dendritic cell (DC) compartment or defective TLR signaling. We analyzed the expression of TLRs 1 to 9 on myeloid DCs generated from XLA patients and evaluated their response to activation by specific TLR agonists. We show that XLA patients have normal numbers of circulating DCs. Btk-deficient DCs have no defect in response to stimulation of TLRs 1/2, 2/6, 3, 4, and 5 but display a profound impairment of IL-6 and TNF-alpha production in response to stimulation by TLR-8 cognate agonist, ssRNA. These findings may provide an explanation for the susceptibility to enteroviral infections in XLA patients.
ER  -

SOCHOROVÁ, Klára; R. HORVÁTH; D. ROZKOVÁ; Jiří LITZMAN; Jiřina BARTŮŇKOVÁ; Anna ŠEDIVÁ a Radek SPÍŠEK. Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia. \textit{Blood}. 2007, roč.~109, č.~6, s.~2553-2556. ISSN~0006-4971.

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