SOCHOROVÁ, Klára, R. HORVÁTH, D. ROZKOVÁ, Jiří LITZMAN, Jiřina BARTŮŇKOVÁ, Anna ŠEDIVÁ a Radek SPÍŠEK. Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia. Blood. 2007, roč. 109, č. 6, s. 2553-2556. ISSN 0006-4971. |
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@article{748682, author = {Sochorová, Klára and Horváth, R. and Rozková, D. and Litzman, Jiří and Bartůňková, Jiřina and Šedivá, Anna and Spíšek, Radek}, article_number = {6}, keywords = {Toll-like receptor; Brutons tyrosine kinase; antigen-presenting cells}, language = {eng}, issn = {0006-4971}, journal = {Blood}, title = {Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia}, volume = {109}, year = {2007} }
TY - JOUR ID - 748682 AU - Sochorová, Klára - Horváth, R. - Rozková, D. - Litzman, Jiří - Bartůňková, Jiřina - Šedivá, Anna - Spíšek, Radek PY - 2007 TI - Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia JF - Blood VL - 109 IS - 6 SP - 2553-2556 EP - 2553-2556 SN - 00064971 KW - Toll-like receptor KW - Brutons tyrosine kinase KW - antigen-presenting cells N2 - The critical role of Bruton tyrosine kinase (Btk) in B cells has been documented by the block of B-cell development in X-linked agammaglobulinemia (XLA). Less is known about Btk function in myeloid cells. Several pieces of evidence indicate that Btk is a component of Toll-like receptor (TLR) signaling. We analyzed whether Btk deficiency in XLA is associated with an impaired dendritic cell (DC) compartment or defective TLR signaling. We analyzed the expression of TLRs 1 to 9 on myeloid DCs generated from XLA patients and evaluated their response to activation by specific TLR agonists. We show that XLA patients have normal numbers of circulating DCs. Btk-deficient DCs have no defect in response to stimulation of TLRs 1/2, 2/6, 3, 4, and 5 but display a profound impairment of IL-6 and TNF-alpha production in response to stimulation by TLR-8 cognate agonist, ssRNA. These findings may provide an explanation for the susceptibility to enteroviral infections in XLA patients. ER -
SOCHOROVÁ, Klára, R. HORVÁTH, D. ROZKOVÁ, Jiří LITZMAN, Jiřina BARTŮŇKOVÁ, Anna ŠEDIVÁ a Radek SPÍŠEK. Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia. \textit{Blood}. 2007, roč.~109, č.~6, s.~2553-2556. ISSN~0006-4971.
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