| TRBUŠEK, Martin, Jitka MALČÍKOVÁ, Jana ŠMARDOVÁ, Viera KUHROVÁ, Dita MENTZLOVÁ, Soňa BUKOVSKÁ, Petr KUGLÍK, Michael DOUBEK, Yvona BRYCHTOVÁ, Šárka POSPÍŠILOVÁ, Dana DVOŘÁKOVÁ, Jiří VORLÍČEK, Jiří MAYER, Miluše SVITÁKOVÁ, Věra LINKOVÁ, Jiří ZAČAL a Jitka KUJÍČKOVÁ. Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation. Leukemia. 2006, roč. 2006, č. 20, s. 1159-1161. ISSN 0887-6924. |
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@article{749045,
author = {Trbušek, Martin and Malčíková, Jitka and Šmardová, Jana and Kuhrová, Viera and Mentzlová, Dita and Bukovská, Soňa and Kuglík, Petr and Doubek, Michael and Brychtová, Yvona and Pospíšilová, Šárka and Dvořáková, Dana and Vorlíček, Jiří and Mayer, Jiří and Svitáková, Miluše and Linková, Věra and Začal, Jiří and Kujíčková, Jitka},
article_number = {20},
keywords = {B-CLL FASAY IgVH p53 ATM previous treatment},
language = {eng},
issn = {0887-6924},
journal = {Leukemia},
title = {Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation},
volume = {2006},
year = {2006}
}
TY - JOUR
ID - 749045
AU - Trbušek, Martin - Malčíková, Jitka - Šmardová, Jana - Kuhrová, Viera - Mentzlová, Dita - Bukovská, Soňa - Kuglík, Petr - Doubek, Michael - Brychtová, Yvona - Pospíšilová, Šárka - Dvořáková, Dana - Vorlíček, Jiří - Mayer, Jiří - Svitáková, Miluše - Linková, Věra - Začal, Jiří - Kujíčková, Jitka
PY - 2006
TI - Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation
JF - Leukemia
VL - 2006
IS - 20
SP - 1159-1161
EP - 1159-1161
SN - 08876924
KW - B-CLL FASAY IgVH p53 ATM previous treatment
N2 - Defects in either of the two cooperating tumor suppressors, p53 or ATM, confer an inferior prognosis for B CLL patients. The abnormalities were reported to be associated with the unmutated IgVH subtype and may thus arise as a consequence of its more aggressive behaviour. However a recent report has also clearly correlated the p53 inactivation to a DNA damaging chemotherapy including alkylating agents (Sturm et al., Cell Death Differ 2003, 10: 477 to 484). We performed a comprehensive determination of p53 status in 168 B CLL samples (including functional FASAY analysis) and a deletion screening of ATM locus in 69% of the corresponding samples and correlated the data to the IgVH mutation status and to previous treatment. Inactivation of the p53 (overall frequency 12%) occurred markedly more frequently (P 0.05) and deletions of ATM (overall frequency 18%) strictly (P 0.001) in the unmutated IgVH subtype. A statistically significant correlation was not achieved between the presence of previous treatment (including alkylating agents in 44/49 cases) and the p53 or ATM abnormalities. In the IgVH unmutated subgroup, where the treatment was markedly more frequent, the proportion of the defects was similar in untreated/treated groups of patients. The p53/ATM inactivation does not seem to be primarily a consequence of DNA damaging chemotherapy.
ER -
TRBUŠEK, Martin, Jitka MALČÍKOVÁ, Jana ŠMARDOVÁ, Viera KUHROVÁ, Dita MENTZLOVÁ, Soňa BUKOVSKÁ, Petr KUGLÍK, Michael DOUBEK, Yvona BRYCHTOVÁ, Šárka POSPÍŠILOVÁ, Dana DVOŘÁKOVÁ, Jiří VORLÍČEK, Jiří MAYER, Miluše SVITÁKOVÁ, Věra LINKOVÁ, Jiří ZAČAL a Jitka KUJÍČKOVÁ. Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation. \textit{Leukemia}. 2006, roč.~2006, č.~20, s.~1159-1161. ISSN~0887-6924.
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