2007
Parasite diversity and major histocompatibility complex: the variation in MHC class IIB in six European populations of chub (Leuciscus cephalus Linnaeus, 1758)
SEIFERTOVÁ, Mária a Andrea ŠIMKOVÁZákladní údaje
Originální název
Parasite diversity and major histocompatibility complex: the variation in MHC class IIB in six European populations of chub (Leuciscus cephalus Linnaeus, 1758)
Autoři
Vydání
15th Helminthological Days, Ředkovec at Světlá nad Sázavou, 14-18 May, 2007
Další údaje
Jazyk
angličtina
Typ výsledku
Prezentace na konferencích
Obor
10600 1.6 Biological sciences
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14310/07:00041712
Organizační jednotka
Přírodovědecká fakulta
ISBN
978-80-210-4689-4
Klíčová slova česky
jelec tloušť MHC diverzita parazitů
Klíčová slova anglicky
parasite diversity MHC chub
Změněno: 8. 3. 2011 09:45, Mgr. Mária Seifertová, Ph.D.
Anotace
V originále
MHC genes are highly polymorphic and are co-dominantly expressed on cells. Our study was focused on MHC II genes, because they are critical for initiation the immune response against extracellular antigens derived from pathogens and parasites. Polymorphism of these genes is maintained by heterozygote advantage (or overdominance hypothesis), rare-allele advantage (or negative frequency dependent selection hypothesis), and disassortative mating, whereas parasites are likely the important selective agents. An influence of parasite diversity on genetic variability of the host’s MHC molecules, concretely of the exon 2, which encodes the beta 1 domain of the peptide binding region and is the most variable site of MHC II molecules, was examined. In six populations of the chub collected from the Czech Republic and France 83 alleles were found. Between 10 and 26 alleles were identified per population, the minimum number of alleles per fish was one and maximum five alleles. 36 species of parasites, representing 8 higher taxa (Monogenea, Crustacea (parasitic Copepoda), Mollusca, Hirudinea, Digenea, Acantocephala, Nematoda and Cestoda), were identified. The highest abundance, prevalence, and mean intensity of infection were characterized for monogenean species.
Návaznosti
| GA524/07/0188, projekt VaV |
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| LC522, projekt VaV |
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| MSM0021622416, záměr |
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