A link between variability of MHC IIB genes and metazoan
parasites in the selected populations of the chub ( Leuciscus
cephalus  Linnaeus, 1758 )

k 2005

A link between variability of MHC IIB genes and metazoan parasites in the selected populations of the chub ( Leuciscus cephalus Linnaeus, 1758 )

STEINEROVÁ, Mária a Andrea ŠIMKOVÁ

Základní údaje

Originální název

A link between variability of MHC IIB genes and metazoan parasites in the selected populations of the chub ( Leuciscus cephalus Linnaeus, 1758 )

Autoři

STEINEROVÁ, Mária (703 Slovensko, garant, domácí) a Andrea ŠIMKOVÁ (703 Slovensko, domácí)

Vydání

13 th Helminthological Days, 2005

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

10600 1.6 Biological sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/05:00041714

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

MHC

Změněno: 4. 3. 2011 10:57, Mgr. Mária Seifertová, Ph.D.

Anotace

V originále

The genes of the MHC (major histocompatibility complex) play a central role in mediating a vertebrate’s immune response to diseases and parasites. The MHC family is divided into two major subfamilies, class I and class II. In the teleost fishes, the class I and II genes are not localized on the same linkage group. The MHC loci are characterized by high levels of polymorphism, and the products of these genes are the sign of individuality. The allelic lineages of MHC are often shared by related species (this feature is called as trans-species polymorphism). Variability of MHC loci is maintained by two main types of mechanisms: the pathogen-driven balancing selection and reproductive mechanisms. There are two basic types of the hypothesis of the pathogen-driven balancing selection: (1) overdominance hypothesis based on the advantage being heterozygotes at MHC alleles, which permits to recognize wider range of antigens derived from the pathogens than in the case of homozygotes, (2) negative frequency dependent selection hypothesis (or rare-allele advantage) proposing that the individuals with a rare MHC allele respond better to new pathogens. The hypothesis of MHC dependent mating preferences proposes that selection of MHC alleles contributing to the immune recognition of pathogens or parasites could be connected with sexual selection which may provide a choice of “good genes” in order to increase the offspring resistance. Considering the class IIB the polymorphism is concentrated in exon 2 corresponding to ß1 domain of this class which includes the peptide binding regions (PBR). The PBR should interact with the parasitic antigens or parasites, the source of the antigen, are likely the selective agents. The goal of this study was to investigate the variability in exon 2 of class II beta-encoding genes (DAB genes) in four populations of the chub (Leuciscus cephalus L.) collected from the different water basins not historically connected, and evaluate the potential role of the metazoan parasites on the MHC genes differentiation. The results indicate the relationship between MHC allelic diversity and parasites.

Návaznosti

LC522, projekt VaV

Název: ICHTYOPARAZITOLOGIE - centrum základního výzkumu

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Ichtyoparazitologie - centrum základního výzkumu

MSM0021622416, záměr

Název: Diverzita biotických společenstev a populací: kauzální analýza variability v prostoru a čase

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Diverzita biotických společenstev: kauzální analýza variability v prostoru a čase

Citovat

STEINEROVÁ, Mária a Andrea ŠIMKOVÁ. A link between variability of MHC IIB genes and metazoan parasites in the selected populations of the chub ( Leuciscus cephalus Linnaeus, 1758 ). In 13 th Helminthological Days. 2005.

@proceedings{749559,
   author = {Steinerová, Mária and Šimková, Andrea},
   booktitle = {13 th Helminthological Days},
   keywords = {MHC},
   language = {eng},
   title = {A link between variability of MHC IIB genes and metazoan parasites in the selected populations of the chub ( Leuciscus cephalus Linnaeus, 1758 )},
   year = {2005}
}

TY  - CONF
ID  - 749559
AU  - Steinerová, Mária - Šimková, Andrea
PY  - 2005
TI  - A link between variability of MHC IIB genes and metazoan parasites in the selected populations of the chub ( Leuciscus cephalus Linnaeus, 1758 )
KW  - MHC
N2  - The genes of the MHC (major histocompatibility complex) play a central role in mediating a vertebrate’s immune response to diseases and parasites. The MHC family is divided into two major subfamilies, class I and class II. In the teleost fishes, the class I and II genes are not localized on the same linkage group. The MHC loci are characterized by high levels of polymorphism, and the products of these genes are the sign of individuality. The allelic lineages of MHC are often shared by related species (this feature is called as trans-species polymorphism). Variability of MHC loci is maintained by two main types of mechanisms: the pathogen-driven balancing selection and reproductive mechanisms. There are two basic types of the hypothesis of the pathogen-driven balancing selection: (1) overdominance hypothesis based on the advantage being heterozygotes at MHC alleles, which permits to recognize wider range of antigens derived from the pathogens than in the case of homozygotes, (2) negative frequency dependent selection hypothesis (or rare-allele advantage) proposing that the individuals with a rare MHC allele respond better to new pathogens. The hypothesis of MHC dependent mating preferences proposes that selection of MHC alleles contributing to the immune recognition of pathogens or parasites could be connected with sexual selection which may provide a choice of “good genes” in order to increase the offspring resistance. Considering the class IIB the polymorphism is concentrated in exon 2 corresponding to ß1 domain of this class which includes the peptide binding regions (PBR). The PBR should interact with the parasitic antigens or parasites, the source of the antigen, are likely the selective agents. The goal of this study was to investigate the variability in exon 2 of class II beta-encoding genes (DAB genes) in four populations of the chub (Leuciscus cephalus L.) collected from the different water basins not historically connected, and evaluate the potential role of the metazoan parasites on the MHC genes differentiation. The results indicate the relationship between MHC allelic diversity and parasites.
ER  -

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