2007
Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy
BERÁNEK, Michal, Petr KOLÁŘ, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ, Anna VAŠKŮ et. al.Základní údaje
Originální název
Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy
Název česky
Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy
Autoři
BERÁNEK, Michal (203 Česká republika, domácí), Petr KOLÁŘ (203 Česká republika), Svatava TSCHÖPLOVÁ (203 Česká republika, domácí), Kateřina KAŇKOVÁ (203 Česká republika, garant, domácí) a Anna VAŠKŮ (203 Česká republika, domácí)
Vydání
Diabetes Res Clin Pract, Elsevier, 2007, 0168-8227
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30202 Endocrinology and metabolism
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.823
Kód RIV
RIV/00216224:14110/07:00020817
Organizační jednotka
Lékařská fakulta
UT WoS
000253370200028
Klíčová slova anglicky
basic fibroblast growth factor; proliferative diabetic retinopathy; haplotype; polymorphisms
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 29. 10. 2012 10:21, prof. MUDr. Petr Kolář, Ph.D.
V originále
The basic fibroblast growth factor (bFGF) is considered to be one of the candidate genes in the processes of tumour growth and angiogenesis. The aim of the present investigation was to find possible association of new polymorphisms in bFGF with proliferative diabetic retinopathy (PDR) and determine the plasma level in PDR. Allele, genotype and haplotype frequencies were determined in the association study comprising three groups of Caucasian subjects (n = 488) (diabetics with/PDR/and without retinopathy/non-PDR/and non-diabetics/ non-DM/) in order to identify genetic marker for PDR. The plasma level of the bFGF protein was analysed by ELISA method. Significantly higher frequencies of 754C allele of the new 754C/G polymorphisms was found between PDR and non-DM group (p=0.05, OR=1.38). The comparison of plasma level of the bFGF showed statistically significant difference among studied groups (p=0.001). The bFGF plasma level in PDR group was significantly higher than in the groups of non-PDR and non-DM (p=0.017, p=0.001, respectively) and was significantly higher for CC and GC genotypes of 754C/G polymorphism in PDR group (p=0.006). Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of PDR. However, the regulatory mechanisms of the bFGF level need further examinations.
Česky
The basic fibroblast growth factor (bFGF) is considered to be one of the candidate genes in the processes of tumour growth and angiogenesis. The aim of the present investigation was to find possible association of new polymorphisms in bFGF with proliferative diabetic retinopathy (PDR) and determine the plasma level in PDR. Allele, genotype and haplotype frequencies were determined in the association study comprising three groups of Caucasian subjects (n = 488) (diabetics with/PDR/and without retinopathy/non-PDR/and non-diabetics/ non-DM/) in order to identify genetic marker for PDR. The plasma level of the bFGF protein was analysed by ELISA method. Significantly higher frequencies of 754C allele of the new 754C/G polymorphisms was found between PDR and non-DM group (p=0.05, OR=1.38). The comparison of plasma level of the bFGF showed statistically significant difference among studied groups (p=0.001). The bFGF plasma level in PDR group was significantly higher than in the groups of non-PDR and non-DM (p=0.017, p=0.001, respectively) and was significantly higher for CC and GC genotypes of 754C/G polymorphism in PDR group (p=0.006). Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of PDR. However, the regulatory mechanisms of the bFGF level need further examinations.
Návaznosti
| GP303/05/P523, projekt VaV |
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