J 2007

Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy

BERÁNEK, Michal, Petr KOLÁŘ, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ, Anna VAŠKŮ et. al.

Základní údaje

Originální název

Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy

Název česky

Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy

Autoři

BERÁNEK, Michal (203 Česká republika, domácí), Petr KOLÁŘ (203 Česká republika), Svatava TSCHÖPLOVÁ (203 Česká republika, domácí), Kateřina KAŇKOVÁ (203 Česká republika, garant, domácí) a Anna VAŠKŮ (203 Česká republika, domácí)

Vydání

Diabetes Res Clin Pract, Elsevier, 2007, 0168-8227

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.823

Kód RIV

RIV/00216224:14110/07:00020817

Organizační jednotka

Lékařská fakulta

UT WoS

000253370200028

Klíčová slova anglicky

basic fibroblast growth factor; proliferative diabetic retinopathy; haplotype; polymorphisms

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 29. 10. 2012 10:21, prof. MUDr. Petr Kolář, Ph.D.

Anotace

V originále

The basic fibroblast growth factor (bFGF) is considered to be one of the candidate genes in the processes of tumour growth and angiogenesis. The aim of the present investigation was to find possible association of new polymorphisms in bFGF with proliferative diabetic retinopathy (PDR) and determine the plasma level in PDR. Allele, genotype and haplotype frequencies were determined in the association study comprising three groups of Caucasian subjects (n = 488) (diabetics with/PDR/and without retinopathy/non-PDR/and non-diabetics/ non-DM/) in order to identify genetic marker for PDR. The plasma level of the bFGF protein was analysed by ELISA method. Significantly higher frequencies of 754C allele of the new 754C/G polymorphisms was found between PDR and non-DM group (p=0.05, OR=1.38). The comparison of plasma level of the bFGF showed statistically significant difference among studied groups (p=0.001). The bFGF plasma level in PDR group was significantly higher than in the groups of non-PDR and non-DM (p=0.017, p=0.001, respectively) and was significantly higher for CC and GC genotypes of 754C/G polymorphism in PDR group (p=0.006). Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of PDR. However, the regulatory mechanisms of the bFGF level need further examinations.

Česky

The basic fibroblast growth factor (bFGF) is considered to be one of the candidate genes in the processes of tumour growth and angiogenesis. The aim of the present investigation was to find possible association of new polymorphisms in bFGF with proliferative diabetic retinopathy (PDR) and determine the plasma level in PDR. Allele, genotype and haplotype frequencies were determined in the association study comprising three groups of Caucasian subjects (n = 488) (diabetics with/PDR/and without retinopathy/non-PDR/and non-diabetics/ non-DM/) in order to identify genetic marker for PDR. The plasma level of the bFGF protein was analysed by ELISA method. Significantly higher frequencies of 754C allele of the new 754C/G polymorphisms was found between PDR and non-DM group (p=0.05, OR=1.38). The comparison of plasma level of the bFGF showed statistically significant difference among studied groups (p=0.001). The bFGF plasma level in PDR group was significantly higher than in the groups of non-PDR and non-DM (p=0.017, p=0.001, respectively) and was significantly higher for CC and GC genotypes of 754C/G polymorphism in PDR group (p=0.006). Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of PDR. However, the regulatory mechanisms of the bFGF level need further examinations.

Návaznosti

GP303/05/P523, projekt VaV
Název: Vztah genetických polymorfizmů v kandidátních genech účastnících se procesu angiogeneze k proliferativní retinopatii u diabetes mellitus 2. typu
Investor: Grantová agentura ČR, Vztah genetických polymorfizmů v kandidátních genech účastnících se procesu angiogeneze k proliferativní retinopatii u diabetes mellitus 2. typu