THE EXPRESSION OF THE Fc GAMMA RECEPTORS (CD16, CD32, CD64) ON
LEUKOCYTES IN THE  COMMON VARIABLE IMMUNODEFICIENCY (CVID)

k 2007

THE EXPRESSION OF THE Fc GAMMA RECEPTORS (CD16, CD32, CD64) ON LEUKOCYTES IN THE COMMON VARIABLE IMMUNODEFICIENCY (CVID)

LOKAJ, Jindřich; Vojtěch THON; Marcela VLKOVÁ; Tomáš FREIBERGER; Jiří LITZMAN et al.

Základní údaje

Originální název

THE EXPRESSION OF THE Fc GAMMA RECEPTORS (CD16, CD32, CD64) ON LEUKOCYTES IN THE COMMON VARIABLE IMMUNODEFICIENCY (CVID)

Název česky

Exprese Fcgama receptorů na leukocytech pacientů s běžným variabilním imunodeficitem(CVID)

Autoři

LOKAJ, Jindřich; Vojtěch THON; Marcela VLKOVÁ; Tomáš FREIBERGER a Jiří LITZMAN

Vydání

13th International Congress of Immunology, 2007

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

30102 Immunology

Stát vydavatele

Brazílie

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

common variable immunodeficiency, Ig Gamma receptors, immune activation

Příznaky

Mezinárodní význam

Změněno: 27. 1. 2008 10:49, prof. MUDr. Jiří Litzman, CSc.

Anotace

ORIG CZ

V originále

CVID is most frequent symptomatic primary hypogammaglobulinemia. The foundation of therapy for CVID is immunoglobulin replacement. The factors that influence the effect of this therapy are not elucidated. It should be supposed participation of receptors for immunoglobulins on professional phagocytes and lymphocytes. We have investigated 41 patients (13 males, 28 females, aged 10-77 years) and 44 age-related control persons. Quantitative expression of the Fc receptors on the surface of lymphocytes, monocytes, and granulocytes was determined by flow cytometry. Gene polymorphism of Fc receptors was determined by PCR. The expression of CD16, CD 32 and CD64 on lymphocytes and monocytes was comparable in patients and control persons, also the expression of CD16 and CD32 on granulocytes was similar in both groups. However, we have found marked differences in the expression of CD64 on granulocytes in CVID patients: in patients with high expression of CD64 on their granulocytes the clinical state and effectivity of standard treatment with intravenous immunoglobulin was significantly worse than in patients with low expression of this receptor. Our results suggest that the gravity in the clinical course of CVID patients and efficacy of immunoglobulin therapy may relate to the upregulation of Fc gamma receptor I (CD64) on granulocytes.

Česky

Sledován výsky exprese Fc gama receptorů na povrchu leukocytů nemocných s běžným variabilním imunodeficitem.

Návaznosti

NR9035, projekt VaV

Název: Specifická protilátková odpověď u pacientů s poruchami imunity

Citovat

LOKAJ, Jindřich; Vojtěch THON; Marcela VLKOVÁ; Tomáš FREIBERGER a Jiří LITZMAN. THE EXPRESSION OF THE Fc GAMMA RECEPTORS (CD16, CD32, CD64) ON LEUKOCYTES IN THE COMMON VARIABLE IMMUNODEFICIENCY (CVID). In 13th International Congress of Immunology. 2007.

@proceedings{751712,
   author = {Lokaj, Jindřich and Thon, Vojtěch and Vlková, Marcela and Freiberger, Tomáš and Litzman, Jiří},
   booktitle = {13th International Congress of Immunology},
   keywords = {common variable immunodeficiency, Ig Gamma receptors, immune activation},
   language = {eng},
   title = {THE EXPRESSION OF THE Fc GAMMA RECEPTORS (CD16, CD32, CD64) ON LEUKOCYTES IN THE COMMON VARIABLE IMMUNODEFICIENCY (CVID)},
   year = {2007}
}

TY  - CONF
ID  - 751712
AU  - Lokaj, Jindřich - Thon, Vojtěch - Vlková, Marcela - Freiberger, Tomáš - Litzman, Jiří
PY  - 2007
TI  - THE EXPRESSION OF THE Fc GAMMA RECEPTORS (CD16, CD32, CD64) ON LEUKOCYTES IN THE COMMON VARIABLE IMMUNODEFICIENCY (CVID)
KW  - common variable immunodeficiency, Ig Gamma receptors, immune activation
N2  - CVID is most frequent symptomatic primary hypogammaglobulinemia. The foundation of therapy for CVID is immunoglobulin replacement. The factors that influence the effect of this therapy are not elucidated. It should be supposed participation of receptors for immunoglobulins on professional phagocytes and lymphocytes. We have investigated 41 patients (13 males, 28 females, aged 10-77 years) and 44 age-related control persons. Quantitative expression of the Fc receptors on the surface of lymphocytes, monocytes, and granulocytes was determined by flow cytometry. Gene polymorphism of Fc receptors was determined by PCR. The expression of CD16, CD 32 and CD64 on lymphocytes and monocytes was comparable in patients and control persons, also the expression of CD16 and CD32 on granulocytes was similar in both groups. However, we have found marked differences in the expression of CD64 on granulocytes in CVID patients: in patients with high expression of CD64 on their granulocytes the clinical state and effectivity of standard treatment with intravenous immunoglobulin was significantly worse than in patients with low expression of this receptor. Our results suggest that the gravity in the clinical course of CVID patients and efficacy of immunoglobulin therapy may relate to the upregulation of Fc gamma receptor I (CD64) on granulocytes.
ER  -

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