| IZAKOVIČOVÁ HOLLÁ, Lydie, Kristína MUSILOVÁ, Jan VOKURKA, Lucie KLAPUŠOVÁ, Pavla PANTŮČKOVÁ, Martina KUKLETOVÁ, Lubomír KUKLA a Vladimír ZNOJIL. The association of interleukin-6 (IL-6) haplotypes with plaque-induced gingivitis in children. Acta Odontologica Scandinavica. Sweden: Informa Healthcare, 2008, roč. 66, č. 2, s. 105-112. ISSN 0001-6357. |
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@article{759327,
author = {Izakovičová Hollá, Lydie and Musilová, Kristína and Vokurka, Jan and Klapušová, Lucie and Pantůčková, Pavla and Kukletová, Martina and Kukla, Lubomír and Znojil, Vladimír},
article_location = {Sweden},
article_number = {2},
keywords = {cytokine; gene; gingivitis; PCR; polymorphism},
language = {eng},
issn = {0001-6357},
journal = {Acta Odontologica Scandinavica},
title = {The association of interleukin-6 (IL-6) haplotypes with plaque-induced gingivitis in children},
volume = {66},
year = {2008}
}
TY - JOUR
ID - 759327
AU - Izakovičová Hollá, Lydie - Musilová, Kristína - Vokurka, Jan - Klapušová, Lucie - Pantůčková, Pavla - Kukletová, Martina - Kukla, Lubomír - Znojil, Vladimír
PY - 2008
TI - The association of interleukin-6 (IL-6) haplotypes with plaque-induced gingivitis in children
JF - Acta Odontologica Scandinavica
VL - 66
IS - 2
SP - 105-112
EP - 105-112
PB - Informa Healthcare
SN - 00016357
KW - cytokine
KW - gene
KW - gingivitis
KW - PCR
KW - polymorphism
N2 - The proinflammatory cytokine interleukin-6 (IL-6) is a key regulator of the host response to microbial infection and major modulator of extracellular matrix catabolism and bone resorption. The aim of this case-control study was to test differences between children with and without gingivitis in distribution of IL-6 alleles at positions -174, -572, and -597 and their haplotypes. Our results indicate that the three promoter polymorphisms in the IL-6 gene act in a cooperative fashion and suggest that IL-6 haplotypes could play a role in the pathogenesis of gingivitis in Caucasian children.
ER -
IZAKOVIČOVÁ HOLLÁ, Lydie, Kristína MUSILOVÁ, Jan VOKURKA, Lucie KLAPUŠOVÁ, Pavla PANTŮČKOVÁ, Martina KUKLETOVÁ, Lubomír KUKLA a Vladimír ZNOJIL. The association of interleukin-6 (IL-6) haplotypes with plaque-induced gingivitis in children. \textit{Acta Odontologica Scandinavica}. Sweden: Informa Healthcare, 2008, roč.~66, č.~2, s.~105-112. ISSN~0001-6357.
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