No association of defined variability in leptin, leptin
receptor, adiponectin, proopiomelanocortin and ghrelin gene
with food preferences in the Czech population

J 2008

No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT, Martin VAVŘINA et. al.

Základní údaje

Originální název

No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population

Název česky

Asociace definované variability v genu pro leptin, leptinový receptor, adiponektin, proopiomelanokortin a ghrelin s potravními preferencemi v české populaci

Autoři

BIENERTOVÁ VAŠKŮ, Julie (203 Česká republika, garant, domácí), Petr BIENERT (203 Česká republika), Josef TOMANDL (203 Česká republika, domácí), Martin FOREJT (203 Česká republika, domácí), Martin VAVŘINA (203 Česká republika, domácí), Jana KUDĚLKOVÁ (203 Česká republika, domácí) a Anna VAŠKŮ (203 Česká republika, domácí)

Vydání

Nutritional Neuroscience, Anglie, W. S. Maney and Son, Ltd, 2008, 1028-415X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.092

Kód RIV

RIV/00216224:14110/08:00033307

Organizační jednotka

Lékařská fakulta

UT WoS

000256999200001

Klíčová slova anglicky

leptin; leptin receptor; proopiomelanocortin; ghrelin; adiponectin; polymorphism; obesity

Štítky

adiponectin, ghrelin, leptin, leptin receptor, obesity, polymorphism, proopiomelanocortin

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 6. 2012 08:51, doc. RNDr. Josef Tomandl, Ph.D.

Anotace

ORIG CZ

V originále

Background: Previously, it has been reported that mutations in the genes encoding for adipokines may be associated with impaired food intake and may serve as potential obesity biomarkers. Aims: The aim of this study was to investigate the possible associations of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin genes with food preferences in obese and non-obese Czech population and evaluate their potential as the obesity susceptibility genes. Material and methods: Using PCR with following restriction analysis, we studied here 185 volunteers. Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7 day record method. In the group of obese individual, a subset of 34 morbidly obese patients was set off that were available for plasma leptin and soluble leptin receptor levels measurement. Results: None of the examined polymorphisms was associated to anthropometrical or demographic characteristics of the study subjects. The Gln223Arg polymorphism within the leptin receptor gene was significantly associated with lower plasma leptin levels (the RR genotype being more frequent in patients with lower plasma leptin levels, p = 0.001). No associations of the examined polymorphisms with food preferences was observed. Conclusion: Based on our results, the examined polymorphisms in the adipokine genes do not seem to be the major risk factors for obesity development in the Czech population nor significantly affect the food preferences.

Česky

Na základě předkládaných výsledků se nedomníváme, že sledované polymorfismy v genech pro adipokiny představují významné genetické markery rizika obezity v české populaci nebo faktory významně ovlivňující stravovací preference sledovaných subjektů.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT, Martin VAVŘINA, Jana KUDĚLKOVÁ a Anna VAŠKŮ. No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population. Nutritional Neuroscience. Anglie: W. S. Maney and Son, Ltd, 2008, roč. 2008, č. 11, s. 2-8. ISSN 1028-415X.

@article{759456,
   author = {Bienertová Vašků, Julie and Bienert, Petr and Tomandl, Josef and Forejt, Martin and Vavřina, Martin and Kudělková, Jana and Vašků, Anna},
   article_location = {Anglie},
   article_number = {11},
   keywords = {leptin; leptin receptor; proopiomelanocortin; ghrelin; adiponectin; polymorphism; obesity},
   language = {eng},
   issn = {1028-415X},
   journal = {Nutritional Neuroscience},
   title = {No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population},
   volume = {2008},
   year = {2008}
}

TY  - JOUR
ID  - 759456
AU  - Bienertová Vašků, Julie - Bienert, Petr - Tomandl, Josef - Forejt, Martin - Vavřina, Martin - Kudělková, Jana - Vašků, Anna
PY  - 2008
TI  - No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population
JF  - Nutritional Neuroscience
VL  - 2008
IS  - 11
SP  - 2-8
EP  - 2-8
PB  - W. S. Maney and Son, Ltd
SN  - 1028415X
KW  - leptin
KW  - leptin receptor
KW  - proopiomelanocortin
KW  - ghrelin
KW  - adiponectin
KW  - polymorphism
KW  - obesity
N2  - Background: Previously, it has been reported that mutations in the genes encoding for adipokines may be associated with impaired food intake and may serve as potential obesity biomarkers. Aims: The aim of this study was to investigate the possible associations of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin genes with food preferences in obese and non-obese Czech population and evaluate their potential as the obesity susceptibility genes. Material and methods: Using PCR with following restriction analysis, we studied here 185 volunteers. Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7 day record method. In the group of obese individual, a subset of 34 morbidly obese patients was set off that were available for plasma leptin and soluble leptin receptor levels measurement. Results: None of the examined polymorphisms was associated to anthropometrical or demographic characteristics of the study subjects. The Gln223Arg polymorphism within the leptin receptor gene was significantly associated with lower plasma leptin levels (the RR genotype being more frequent in patients with lower plasma leptin levels, p = 0.001). No associations of the examined polymorphisms with food preferences was observed. Conclusion: Based on our results, the examined polymorphisms in the adipokine genes do not seem to be the major risk factors for obesity development in the Czech population nor significantly affect the food preferences.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT, Martin VAVŘINA, Jana KUDĚLKOVÁ a Anna VAŠKŮ. No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population. \textit{Nutritional Neuroscience}. Anglie: W. S. Maney and Son, Ltd, 2008, roč.~2008, č.~11, s.~2-8. ISSN~1028-415X.

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