Prognostic significance of chromosomal changes in patients with
multiple myeloma

a 2008

Prognostic significance of chromosomal changes in patients with multiple myeloma

GREŠLIKOVÁ, Henrieta, Petr KUGLÍK, Hana FILKOVÁ, Romana ZAORALOVÁ, Pavel NĚMEC et. al.

Základní údaje

Originální název

Prognostic significance of chromosomal changes in patients with multiple myeloma

Název česky

Prognostický význam chromozómových zmien u pacientov s mnohopočetným myelomom

Autoři

GREŠLIKOVÁ, Henrieta, Petr KUGLÍK, Hana FILKOVÁ, Romana ZAORALOVÁ, Pavel NĚMEC, Alexandra OLTOVÁ, Luděk POUR, Jana SMEJKALOVÁ, Marta KREJČÍ a Roman HÁJEK

Vydání

XII.Setkání biochemikú a molekulárních biologú, 2008

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

Genetika a molekulární biologie

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

ISBN

978-80-210-4526-2

Klíčová slova anglicky

Multiple Myeloma;cIg-FISH;13q deletion;IGH rearrangement;17p13 deletion

Štítky

13q deletion, 17p13 deletion, cIg-FISH, IGH rearrangement, multiple myeloma

Změněno: 4. 5. 2009 10:23, Mgr. Romana Zaoralová

Anotace

ORIG CZ

V originále

Background Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups.The aim of this study was to determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 68 newly diagnosed patients with MM, median of follow-up 35 months, median age 57 years (39-67), DS stadium: stage I 5.9%, II 25%, III 69.1%; A/B - 83.8%/16.2%. Results Overall response (OR) rate after AT was 85.3% including 20.6% CR, 30.9% VGPR and 33.8% PR. Median of time to progression (TTP) was 25.6 (0.4-41.4) months. Median of overall survival (OS) was not reached (0.4-48.5) months. The aberration of the chromosome 13 was found in 53% (35/66), IGH rearrangements in 56% (36/64), t(11;14) in 18.5% (12/64), t(4;14) in 23% (15/64) and deletion of 17p13 in 15.5% (8/51) pts. We have correlated standard prognostic factors (MIG, LD, B2M, Hb, CRP, Ca, albumin), TTP, progression free survival (PFS), duration of response (DOR) and OS with the occurrence of the mentioned aberrations. Lower albumin and lower LD concentrations were detected in patients with aberration of chromosome 13. We have observed shorter OSin patients with IGH rearrangements and then in pts without this change (p=0,029). We have found no significant difference when compared incidence of other chromosomal aberration for TTP, DOR, PFS and OS. Summary/Conclusion We have analysed data of the homogenous group of patients undergoing autologous transplantation in the CMG trial of Czech Myeloma Group. Based on the results we conclude that patients with deletion of 13q14 have lower albumin and lower LD concentration.

Česky

Práca pojednává o význame vybraných chromozomových zmien a ich vztahu k štandardným prognostickým faktorom u novodiagnostikovaných pacientov s mnohopočetným myelomem léčených vysokodávkovou chemoterapiou a následnou autológnou transplantáciou kostnej drene.

Návaznosti

NR8183, projekt VaV

Název: Molekulárně-cytogenetická analýza značených plazmatických buněk a prognostický význam klonálních chromosomových aberací u mnohočetného myelomu

NR9317, projekt VaV

Název: Prognostický význam klonálních chromosomových aberací při použití nových léčebných metod u mnohočetného myelomu

Citovat

GREŠLIKOVÁ, Henrieta, Petr KUGLÍK, Hana FILKOVÁ, Romana ZAORALOVÁ, Pavel NĚMEC, Alexandra OLTOVÁ, Luděk POUR, Jana SMEJKALOVÁ, Marta KREJČÍ a Roman HÁJEK. Prognostic significance of chromosomal changes in patients with multiple myeloma. In XII.Setkání biochemikú a molekulárních biologú. 2008. ISBN 978-80-210-4526-2.

@proceedings{761343,
   author = {Grešliková, Henrieta and Kuglík, Petr and Filková, Hana and Zaoralová, Romana and Němec, Pavel and Oltová, Alexandra and Pour, Luděk and Smejkalová, Jana and Krejčí, Marta and Hájek, Roman},
   booktitle = {XII.Setkání biochemikú a molekulárních biologú},
   keywords = {Multiple Myeloma;cIg-FISH;13q deletion;IGH rearrangement;17p13 deletion},
   language = {eng},
   isbn = {978-80-210-4526-2},
   title = {Prognostic significance of chromosomal changes in patients with multiple myeloma},
   year = {2008}
}

TY  - CONF
ID  - 761343
AU  - Grešliková, Henrieta - Kuglík, Petr - Filková, Hana - Zaoralová, Romana - Němec, Pavel - Oltová, Alexandra - Pour, Luděk - Smejkalová, Jana - Krejčí, Marta - Hájek, Roman
PY  - 2008
TI  - Prognostic significance of chromosomal changes in patients with multiple myeloma
SN  - 9788021045262
KW  - Multiple Myeloma;cIg-FISH;13q deletion;IGH rearrangement;17p13 deletion
N2  - Background Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups.The aim of this study was to determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 68 newly diagnosed patients with MM, median of follow-up 35 months, median age 57 years (39-67), DS stadium: stage I 5.9%, II 25%, III 69.1%; A/B - 83.8%/16.2%. Results Overall response (OR) rate after AT was 85.3% including 20.6% CR, 30.9% VGPR and 33.8% PR. Median of time to progression (TTP) was 25.6 (0.4-41.4) months. Median of overall survival (OS) was not reached (0.4-48.5) months. The aberration of the chromosome 13 was found in 53% (35/66), IGH rearrangements in 56% (36/64), t(11;14) in 18.5% (12/64), t(4;14) in 23% (15/64) and deletion of 17p13 in 15.5% (8/51) pts. We have correlated standard prognostic factors (MIG, LD, B2M, Hb, CRP, Ca, albumin), TTP, progression free survival (PFS), duration of response (DOR) and OS with the occurrence of the mentioned aberrations. Lower albumin and lower LD concentrations were detected in patients with aberration of chromosome 13. We have observed shorter OSin patients with IGH rearrangements and then in pts without this change (p=0,029). We have found no significant difference when compared incidence of other chromosomal aberration for TTP, DOR, PFS and OS. Summary/Conclusion We have analysed data of the homogenous group of patients undergoing autologous transplantation in the CMG trial of Czech Myeloma Group. Based on the results we conclude that patients with deletion of 13q14 have lower albumin and lower LD concentration.
ER  -

GREŠLIKOVÁ, Henrieta, Petr KUGLÍK, Hana FILKOVÁ, Romana ZAORALOVÁ, Pavel NĚMEC, Alexandra OLTOVÁ, Luděk POUR, Jana SMEJKALOVÁ, Marta KREJČÍ a Roman HÁJEK. Prognostic significance of chromosomal changes in patients with multiple myeloma. In \textit{XII.Setkání biochemikú a molekulárních biologú}. 2008. ISBN~978-80-210-4526-2.

Podrobný výpis o publikaci