FOERSTROVÁ, Michaela, Zuzana JANDUROVÁ, Fernanda MARQUES, Gano LURDES, Přemysl LUBAL, Jakub VANĚK, Petr HERMANN a Isabel SANTOS. Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt). Journal of Inorganic Biochemistry. Amsterdam: Elsevier Science, 2008, roč. 102, č. 7, s. 1531-1540. ISSN 0162-0134. |
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@article{769328, author = {Foerstrová, Michaela and Jandurová, Zuzana and Marques, Fernanda and Lurdes, Gano and Lubal, Přemysl and Vaněk, Jakub and Hermann, Petr and Santos, Isabel}, article_location = {Amsterdam}, article_number = {7}, keywords = {Radiopharmaceuticals; macrocyclic and phosphonate complexes; cyclen derivative; DOTA analogue; lanthanide complexes; radiolanthanides; biodistribution; stability constants; formation and decomplexation kinetics}, language = {eng}, issn = {0162-0134}, journal = {Journal of Inorganic Biochemistry}, title = {Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt)}, volume = {102}, year = {2008} }
TY - JOUR ID - 769328 AU - Foerstrová, Michaela - Jandurová, Zuzana - Marques, Fernanda - Lurdes, Gano - Lubal, Přemysl - Vaněk, Jakub - Hermann, Petr - Santos, Isabel PY - 2008 TI - Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt) JF - Journal of Inorganic Biochemistry VL - 102 IS - 7 SP - 1531-1540 EP - 1531-1540 PB - Elsevier Science SN - 01620134 KW - Radiopharmaceuticals KW - macrocyclic and phosphonate complexes KW - cyclen derivative KW - DOTA analogue KW - lanthanide complexes KW - radiolanthanides KW - biodistribution KW - stability constants KW - formation and decomplexation kinetics N2 - The novel methylphosphonic acid monoethylester (H4dotpOEt) has been synthesized and characterized and their complexes with Sm(III) and Ho(III) ions were studied. Dissociation constants of the ligand are lower than those of H4dota. The stability constants of the Ln(III)-H4dotpOEt complexes are surprisingly much lower that those of H4dota probably due to a lower coordination ability of the phosphonate monoester groups. Acid-assisted decomplexation studies have shown that both complexes are less kinetically inert than the H4dota complexes, but still much more inert than complexes of open-chain ligands. Nevertheless, the synthesis of 153Sm and 166Ho complexes with this ligand led to stable complexes both in vitro and in vivo. A very low binding of these complexes to hydroxyapatite (HA) and calcified tissues was observed confirming the assumption that a fully ionized phosphonate group(s) is necessary for a strong bone affinity. Both complexes show similar behaviour in vivo. ER -
FOERSTROVÁ, Michaela, Zuzana JANDUROVÁ, Fernanda MARQUES, Gano LURDES, Přemysl LUBAL, Jakub VANĚK, Petr HERMANN a Isabel SANTOS. Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt). \textit{Journal of Inorganic Biochemistry}. Amsterdam: Elsevier Science, 2008, roč.~102, č.~7, s.~1531-1540. ISSN~0162-0134.
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