The effects of chronic corticosterone on hippocampal astrocyte
numbers:  A comparison of male and female Wistar rats

J 2008

The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats

BRIDGES, Nikola, Karel ŠLAIS a Eva SYKOVÁ

Základní údaje

Originální název

The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats

Název česky

Vliv chronického podávání kortikosteronu na počet astrocytů v hipokampu: srovnání samců a samic potkana kmene Wistar

Autoři

BRIDGES, Nikola (826 Velká Británie a Severní Irsko), Karel ŠLAIS (203 Česká republika, garant) a Eva SYKOVÁ (203 Česká republika)

Vydání

Acta Neurobiologiae Experimentalis, Warsaw, Nencki Institute of Experimental Biology, 2008, 0065-1400

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.091

Kód RIV

RIV/00216224:14110/08:00026151

Organizační jednotka

Lékařská fakulta

UT WoS

000258083200001

Klíčová slova anglicky

astrocyte; corticosterone; hippocampus; rat; sex differences

Štítky

astrocyte, corticosterone, hippocampus, rat, sex differences

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 6. 2009 09:27, MUDr. Mgr. Karel Šlais, Ph.D.

Anotace

ORIG CZ

V originále

In the present study, we investigated the total percentage body weight, hippocampal volume and hippocampal astrocyte numbers following chronic corticosterone treatment in male and female Wistar rats. Males had greater left and right hippocampal volumes overall, but no effect on hippocampal volume was seen after corticosterone treatment. Total body weight was dose-dependently lower in both sexes, but the decrease was more prominent in male rats. Corticosterone treatment dose-dependently increased astrocyte numbers in the CA1 region, but not in the lateral and medial CA3 hippocampal regions. This increase was similar in both male and female rats.

Česky

Tato práce studovala změny hmotnosti, velikosti hipokampu a počet astrocytů v hipokampu u samců a samic potkana kmene Wistar po dlouhodobém podávání kortikosteronu.

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

BRIDGES, Nikola, Karel ŠLAIS a Eva SYKOVÁ. The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats. Acta Neurobiologiae Experimentalis. Warsaw: Nencki Institute of Experimental Biology, 2008, roč. 68, č. 2, s. 131-138. ISSN 0065-1400.

@article{770612,
   author = {Bridges, Nikola and Šlais, Karel and Syková, Eva},
   article_location = {Warsaw},
   article_number = {2},
   keywords = {astrocyte; corticosterone; hippocampus; rat; sex differences},
   language = {eng},
   issn = {0065-1400},
   journal = {Acta Neurobiologiae Experimentalis},
   title = {The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats},
   url = {http://www.ane.pl/linkout.php?pii=6817&vol=68&no=2&fpp=131},
   volume = {68},
   year = {2008}
}

TY  - JOUR
ID  - 770612
AU  - Bridges, Nikola - Šlais, Karel - Syková, Eva
PY  - 2008
TI  - The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats
JF  - Acta Neurobiologiae Experimentalis
VL  - 68
IS  - 2
SP  - 131-138
EP  - 131-138
PB  - Nencki Institute of Experimental Biology
SN  - 00651400
KW  - astrocyte
KW  - corticosterone
KW  - hippocampus
KW  - rat
KW  - sex differences
UR  - http://www.ane.pl/linkout.php?pii=6817&vol=68&no=2&fpp=131
N2  - In the present study, we investigated the total percentage body weight, hippocampal volume and hippocampal astrocyte numbers following chronic corticosterone treatment in male and female Wistar rats. Males had greater left and right hippocampal volumes overall, but no effect on hippocampal volume was seen after corticosterone treatment. Total body weight was dose-dependently lower in both sexes, but the decrease was more prominent in male rats. Corticosterone treatment dose-dependently increased astrocyte numbers in the CA1 region, but not in the lateral and medial CA3 hippocampal regions. This increase was similar in both male and female rats.
ER  -

BRIDGES, Nikola, Karel ŠLAIS a Eva SYKOVÁ. The effects of chronic corticosterone on hippocampal astrocyte numbers: A comparison of male and female Wistar rats. \textit{Acta Neurobiologiae Experimentalis}. Warsaw: Nencki Institute of Experimental Biology, 2008, roč.~68, č.~2, s.~131-138. ISSN~0065-1400.

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