A model of the guinea-pig ventricular cardiac myocyte
incorporating a transverse-axial tubular system

J 2008

A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system

PÁSEK, Michal, Jiří ŠIMURDA, C. ORCHARD a G. CHRISTÉ

Základní údaje

Originální název

A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system

Název česky

Model srdeční komorové buňky morčete zahrnující transverzálně-axiální tubulární systém

Autoři

PÁSEK, Michal (203 Česká republika, garant), Jiří ŠIMURDA (203 Česká republika, domácí), C. ORCHARD (826 Velká Británie a Severní Irsko) a G. CHRISTÉ (250 Francie)

Vydání

Progress in Biophysics and Molecular Biology, Great Britain, Elsevier Ltd. 2008, 0079-6107

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 6.388

Kód RIV

RIV/00216224:14110/08:00024217

Organizační jednotka

Lékařská fakulta

UT WoS

000254598000015

Klíčová slova anglicky

guinea pig; cardiac cell; transverse-axial tubular system; quantitative model

Štítky

Cardiac cell, guinea pig, quantitative model, transverse-axial tubular system

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 12. 2012 17:24, doc. Ing. Michal Pásek, Ph.D.

Anotace

ORIG CZ

V originále

A model of guinea-pig cardiac ventricular myocyte incorporating a transverse-axial tubular system (TATS) was developed. The model reproduces frequency-dependent changes of action potential shape and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes.Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp. However, during action potentials, restricted diffusion and ionic currents in TATS cause depletion of tubular Ca2+ and accumulation of tubular K+ (up to 19.8% and +3.4%, respectively, of bulk extracellular values, at 6 Hz). These changes, in turn, decrease ion fluxes across the TATS membrane and decrease sarcoplasmic reticulum (SR) Ca2+ load. Thus, the TATS plays a potentially important role in modulating the function of guinea-pig ventricular myocyte in physiological conditions.

Česky

Práce prezentuje matematický model elektrické aktivity srdeční komorové buňky morčete zahrnující funkci transverzálně axiálního tubulárního systému (TATS). Představené výsledky simulací odhalují fyziologický význam TATS u srdečních buněk.

Návaznosti

MSM0021622402, záměr

Název: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob

Citovat

PÁSEK, Michal, Jiří ŠIMURDA, C. ORCHARD a G. CHRISTÉ. A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system. Progress in Biophysics and Molecular Biology. Great Britain: Elsevier Ltd., 2008, roč. 96, 1-3, s. 258-280. ISSN 0079-6107.

@article{770899,
   author = {Pásek, Michal and Šimurda, Jiří and Orchard, C. and Christé, G.},
   article_location = {Great Britain},
   article_number = {1-3},
   keywords = {guinea pig; cardiac cell; transverse-axial tubular system; quantitative model},
   language = {eng},
   issn = {0079-6107},
   journal = {Progress in Biophysics and Molecular Biology},
   title = {A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system},
   volume = {96},
   year = {2008}
}

TY  - JOUR
ID  - 770899
AU  - Pásek, Michal - Šimurda, Jiří - Orchard, C. - Christé, G.
PY  - 2008
TI  - A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system
JF  - Progress in Biophysics and Molecular Biology
VL  - 96
IS  - 1-3
SP  - 258-280
EP  - 258-280
PB  - Elsevier Ltd.
SN  - 00796107
KW  - guinea pig
KW  - cardiac cell
KW  - transverse-axial tubular system
KW  - quantitative model
N2  - A model of guinea-pig cardiac ventricular myocyte incorporating a transverse-axial tubular system (TATS) was developed. The model reproduces frequency-dependent changes of action potential shape and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes.Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp. However, during action potentials, restricted diffusion and ionic currents in TATS cause depletion of tubular Ca2+ and accumulation of tubular K+ (up to 19.8% and +3.4%, respectively, of bulk extracellular values, at 6 Hz). These changes, in turn, decrease ion fluxes across the TATS membrane and decrease sarcoplasmic reticulum (SR) Ca2+ load. Thus, the TATS plays a potentially important role in modulating the function of guinea-pig ventricular myocyte in physiological conditions.
ER  -

PÁSEK, Michal, Jiří ŠIMURDA, C. ORCHARD a G. CHRISTÉ. A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system. \textit{Progress in Biophysics and Molecular Biology}. Great Britain: Elsevier Ltd., 2008, roč.~96, 1-3, s.~258-280. ISSN~0079-6107.

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