Další formáty:
BibTeX
LaTeX
RIS
@article{770899, author = {Pásek, Michal and Šimurda, Jiří and Orchard, C. and Christé, G.}, article_location = {Great Britain}, article_number = {1-3}, keywords = {guinea pig; cardiac cell; transverse-axial tubular system; quantitative model}, language = {eng}, issn = {0079-6107}, journal = {Progress in Biophysics and Molecular Biology}, title = {A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system}, volume = {96}, year = {2008} }
TY - JOUR ID - 770899 AU - Pásek, Michal - Šimurda, Jiří - Orchard, C. - Christé, G. PY - 2008 TI - A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system JF - Progress in Biophysics and Molecular Biology VL - 96 IS - 1-3 SP - 258-280 EP - 258-280 PB - Elsevier Ltd. SN - 00796107 KW - guinea pig KW - cardiac cell KW - transverse-axial tubular system KW - quantitative model N2 - A model of guinea-pig cardiac ventricular myocyte incorporating a transverse-axial tubular system (TATS) was developed. The model reproduces frequency-dependent changes of action potential shape and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes.Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp. However, during action potentials, restricted diffusion and ionic currents in TATS cause depletion of tubular Ca2+ and accumulation of tubular K+ (up to 19.8% and +3.4%, respectively, of bulk extracellular values, at 6 Hz). These changes, in turn, decrease ion fluxes across the TATS membrane and decrease sarcoplasmic reticulum (SR) Ca2+ load. Thus, the TATS plays a potentially important role in modulating the function of guinea-pig ventricular myocyte in physiological conditions. ER -
PÁSEK, Michal, Jiří ŠIMURDA, C. ORCHARD a G. CHRISTÉ. A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system. \textit{Progress in Biophysics and Molecular Biology}. Great Britain: Elsevier Ltd., 2008, roč.~96, 1-3, s.~258-280. ISSN~0079-6107.
|