2008
Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients
ŠPINAROVÁ, Lenka, Jindřich ŠPINAR, Anna VAŠKŮ, Monika PÁVKOVÁ GOLDBERGOVÁ, Ondřej LUDKA et. al.Základní údaje
Originální název
Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients
Název česky
Genetika humorální a cytokinové aktivace u srdečního selhání a její význam pro stratifikaci rizika pacientů
Autoři
ŠPINAROVÁ, Lenka (203 Česká republika, garant, domácí), Jindřich ŠPINAR (203 Česká republika, domácí), Anna VAŠKŮ (203 Česká republika, domácí), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Česká republika, domácí), Ondřej LUDKA (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí) a Jiří VÍTOVEC (203 Česká republika, domácí)
Vydání
Experimental and Molecular Pathology, USA, The Human Press, 2008, 0014-4800
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30201 Cardiac and Cardiovascular systems
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.930
Kód RIV
RIV/00216224:14110/08:00026223
Organizační jednotka
Lékařská fakulta
UT WoS
000257725700011
Klíčová slova anglicky
Genetics;cytokines;chronic hear failure;stratification
Štítky
Příznaky
Recenzováno
Změněno: 6. 6. 2012 08:49, doc. RNDr. Josef Tomandl, Ph.D.
V originále
Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. Patients with ischemic heart disease (IHD) and previous MI showed a difference in the distribution of genotype G8002A for endothelin-1: allele G 0.718 and A 0.282 vs those without MI: allele G 0.882 and A 0.118, (p < 0.05). Patients with IHD and DM had allele G in 0.67 and A 0.33, while those without DM had allele G in 0.790 and A in 0.209 (p < 0.03). Patients with IHD and concomitant PAD had allele G in 0.718 and A in 0.282 vs those without PAD allele G in 0.882 and A in 0.118 (p < 0.0004). Patients with dilative cardiomyopathy (DCMP) showed no differences in genotype G8002A and presence of DM or PAD. It might be speculated that in the case of endothelin-1 and TNF alpha in CHF the genetic determination is not important, and plasma concentrations are influenced more by the disease severity. Ischemics with previous MI, concomitant DM or PAD showed more frequently allele A and less often allele G than those without these diseases. A genotype with allele A is associated with higher risk of concomitant diseases.
Česky
Genetika humorální a cytokinové aktivace u srdečního selhání a její význam pro stratifikaci rizika pacientů. Patients with ischemic heart disease (IHD) and previous MI showed a difference in the distribution of genotype G8002A for endothelin-1: allele G 0.718 and A 0.282 vs those without MI: allele G 0.882 and A 0.118, (p < 0.05). Patients with IHD and DM had allele G in 0.67 and A 0.33, while those without DM had allele G in 0.790 and A in 0.209 (p < 0.03). Patients with IHD and concomitant PAD had allele G in 0.718 and A in 0.282 vs those without PAD allele G in 0.882 and A in 0.118 (p < 0.0004). Patients with dilative cardiomyopathy (DCMP) showed no differences in genotype G8002A and presence of DM or PAD. It might be speculated that in the case of endothelin-1 and TNF alpha in CHF the genetic determination is not important, and plasma concentrations are influenced more by the disease severity. Ischemics with previous MI, concomitant DM or PAD showed more frequently allele A and less often allele G than those without these diseases. A genotype with allele A is associated with higher risk of concomitant diseases.
Návaznosti
| MSM0021622402, záměr |
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