Effect of anandamide uptake inhibitor O-2093 on aggressivity in
mice

J 2008

Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice

ŠLAIS, Karel a Alexandra ŠULCOVÁ

Základní údaje

Originální název

Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice

Název česky

Účinky inhibitoru zpětného vstřebávání anandamidu O-2093 na agresivitu u myší

Autoři

ŠLAIS, Karel a Alexandra ŠULCOVÁ

Vydání

The International Journal of Neuropsychopharmacology, Cambridge, Cambridge University Press, 2008, 1461-1457

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.378

Organizační jednotka

Lékařská fakulta

UT WoS

000258855501258

Klíčová slova anglicky

O-2093; aggressivity; mouse; behaviour

Štítky

aggressivity, behaviour, mouse, O-2093

Příznaky

Mezinárodní význam

Změněno: 24. 6. 2009 13:10, MUDr. Mgr. Karel Šlais, Ph.D.

Anotace

ORIG CZ

V originále

Testing effects of endocannabinoid anandamide on mouse behaviour on paired conflict social interactions we have found its inhibitory influence on aggressive activities in aggressive isolates and pro-aggressive effects in timid mice exhibiting on control interaction defensive-escape behaviour but no attacks. The aim of this study was to ascertain if the anandamide uptake inhibitor O-2093 can elicit similar behavioural changes on mouse agonist behaviour as anandamide as well as other cannabinoid receptor agonist previously tested (HU-210, methanandamide).In timid mice (n=11), all doses of O-2093 tested caused significant increase of aggressive behavioural acts (tail rattling, unrest, attack of the partner). We observed no changes in behaviour of aggressive mice. The present findings confirmed that inhibition of anandamide uptake is able to produce analogical pro-aggressive effects as administration of anandamide in mice showing on social conflict timidity. On the contrary, the suspected enhanced physiological effect of anandamide after administration of its uptake inhibitor was insufficient to produced reduction of aggressive activities in aggressive singly-housed mice measured earlier after exogenously given anadamide.

Česky

Práce popisuje účinky inhibitoru zpětného vychytávání anandamidu O-2093 na agresivitu v testu agonistických interakcí samostatně chovaných myších samců se skupinově ustájenými zvířaty. Po podání O-2093 bylo prokázáno zvášení agresivity u plachých myší.

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

ŠLAIS, Karel a Alexandra ŠULCOVÁ. Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice. The International Journal of Neuropsychopharmacology. Cambridge: Cambridge University Press, 2008, roč. 11, Supp 1, s. 235. ISSN 1461-1457.

@article{772778,
   author = {Šlais, Karel and Šulcová, Alexandra},
   article_location = {Cambridge},
   article_number = {Supp 1},
   keywords = {O-2093; aggressivity; mouse; behaviour},
   language = {eng},
   issn = {1461-1457},
   journal = {The International Journal of Neuropsychopharmacology},
   title = {Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice},
   volume = {11},
   year = {2008}
}

TY  - JOUR
ID  - 772778
AU  - Šlais, Karel - Šulcová, Alexandra
PY  - 2008
TI  - Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice
JF  - The International Journal of Neuropsychopharmacology
VL  - 11
IS  - Supp 1
SP  - 235
EP  - 235
PB  - Cambridge University Press
SN  - 14611457
KW  - O-2093
KW  - aggressivity
KW  - mouse
KW  - behaviour
N2  - Testing effects of endocannabinoid anandamide on mouse behaviour on paired conflict social interactions we have found its inhibitory influence on aggressive activities in aggressive isolates and pro-aggressive effects in timid mice exhibiting on control interaction defensive-escape behaviour but no attacks. The aim of this study was to ascertain if the anandamide uptake inhibitor O-2093 can elicit similar behavioural changes on mouse agonist behaviour as anandamide as well as other cannabinoid receptor agonist previously tested (HU-210, methanandamide).In timid mice (n=11), all doses of O-2093 tested caused significant increase of aggressive behavioural acts (tail rattling, unrest, attack of the partner). We observed no changes in behaviour of aggressive mice. The present findings confirmed that inhibition of anandamide uptake is able to produce analogical pro-aggressive effects as administration of anandamide in mice showing on social conflict timidity. On the contrary, the suspected enhanced physiological effect of anandamide after administration of its uptake inhibitor was insufficient to produced reduction of aggressive activities in aggressive singly-housed mice measured earlier after exogenously given anadamide.
ER  -

ŠLAIS, Karel a Alexandra ŠULCOVÁ. Effect of anandamide uptake inhibitor O-2093 on aggressivity in mice. \textit{The International Journal of Neuropsychopharmacology}. Cambridge: Cambridge University Press, 2008, roč.~11, Supp 1, s.~235. ISSN~1461-1457.

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