Repeated exposure to methamphetamine and methanandamide changes relative expression of D1 receptor in mouse midbrain

LANDA, Leoš and Michal JURAJDA. Repeated exposure to methamphetamine and methanandamide changes relative expression of D1 receptor in mouse midbrain. European Neuropsychopharmacology. Amsterdam: Elsevier, 2008, vol. 18, Suppl. 4, p. S542-S543, 2 pp. ISSN 0924-977X.

Basic information

Original name

Repeated exposure to methamphetamine and methanandamide changes relative expression of D1 receptor in mouse midbrain

Name in Czech

Opakovaná expozice metamfetaminu a metanandamidu mění relativní expresi D1 receptorů ve středním mozku myší

Authors

LANDA, Leoš and Michal JURAJDA

Edition

European Neuropsychopharmacology, Amsterdam, Elsevier, 2008, 0924-977X

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Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Spain

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 3.661

Organization unit

Faculty of Medicine

UT WoS

000259593801381

Keywords in English

PCR; behavioural sensitization; methamphetamine; cannabinoids; D1 receptor; mesencephalon

Tags

behavioural sensitization, cannabinoids, D1 receptor, mesencephalon, methamphetamine, PCR

Tags

International impact, Reviewed

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Abstract

In the original language

The results of the behavioural investigation showed: a) significant stimulatory influence of methamphetamine after the acute administration, b) development of sensitization to methamphetamine after its repeated treatment, c) development of cross-sensitization to methamphetamine after repeated pre-treatment with CB1 receptor agonist methanandamide. Real-time PCR results showed increased D1 mRNA expression both in animals sensitized to methamphetamine and in animals cross-sensitized to methamphetamine (repeatedly pre-treated with methanandamide).

In Czech

Výsledky behaviorální části experimentu ukázaly: a) signifikantní stimulační vliv metamfetaminu po akutním podání, b) rozvoj senzitizace k metamfetaminu po opakovaném podávání, c) rozvoj zkřížené senzitizace k metamfetaminu po opakované předcházející aplikaci agonisty CB1 receptorů metanandamidu. Výsledky real-time PCR ukázaly zvýšenou expresi D1 mRNA jak u zvířat senzitizovaných k metamfetaminu, tak u zvířat se zkříženou senzitizací k metamfetaminu (po opakované předchozí aplikaci metanandamidu).

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Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.